Interferon-β and interferon-γ are weak inhibitors of ebola virus in cell-based assays

Julie Dyall, Brit J. Hart, Elena Postnikova, Yu Cong, Huanying Zhou, Dawn M. Gerhardt, Denise Freeburger, Julia Michelotti, Anna N. Honko, Lisa Evans DeWald, Richard S. Bennett, Gene G. Olinger, Peter B. Jahrling, Lisa E. Hensley

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Previous studies have demonstrated little efficacy of interferons (IFNs) in animal models of Ebola virus disease. However, these studies were limited to a small number of type I IFNs and, during the most recent outbreak of Ebola virus, questions regarding the suitability of the animal models to evaluate IFNs were raised. To address the potential that anti-Ebola virus activity was overlooked, type I and type II IFNs (α-2a, α-2b, -β, -γ, and -universal) were tested in a variety of cell types (Vero E6, Huh 7 cells, and human macrophages). IFNs are weak inhibitors of Ebola virus Makona in these cell lines.

Original languageEnglish (US)
Pages (from-to)1416-1420
Number of pages5
JournalJournal of Infectious Diseases
Issue number9
StatePublished - May 1 2017
Externally publishedYes


  • antiviral
  • Ebola virus
  • interferon

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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