Interferon-β and interferon-γ are weak inhibitors of ebola virus in cell-based assays

Julie Dyall; Brit J. Hart; Elena Postnikova; Yu Cong; Huanying Zhou; Dawn M. Gerhardt; Denise Freeburger; Julia Michelotti; Anna N. Honko; Lisa Evans DeWald; Richard S. Bennett; Gene G. Olinger; Peter B. Jahrling; Lisa E. Hensley

doi:10.1093/infdis/jix134

Interferon-β and interferon-γ are weak inhibitors of ebola virus in cell-based assays

Julie Dyall
, Brit J. Hart
, Elena Postnikova
, Yu Cong
, Huanying Zhou
, Dawn M. Gerhardt
, Denise Freeburger
, Julia Michelotti
, Anna N. Honko
, Lisa Evans DeWald
, Richard S. Bennett
, Gene G. Olinger
, Peter B. Jahrling
, Lisa E. Hensley

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Previous studies have demonstrated little efficacy of interferons (IFNs) in animal models of Ebola virus disease. However, these studies were limited to a small number of type I IFNs and, during the most recent outbreak of Ebola virus, questions regarding the suitability of the animal models to evaluate IFNs were raised. To address the potential that anti-Ebola virus activity was overlooked, type I and type II IFNs (α-2a, α-2b, -β, -γ, and -universal) were tested in a variety of cell types (Vero E6, Huh 7 cells, and human macrophages). IFNs are weak inhibitors of Ebola virus Makona in these cell lines.

Original language	English (US)
Pages (from-to)	1416-1420
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	215
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jix134
State	Published - May 1 2017
Externally published	Yes

Keywords

antiviral
Ebola virus
interferon

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jix134

Cite this

Dyall, J., Hart, B. J., Postnikova, E., Cong, Y., Zhou, H., Gerhardt, D. M., Freeburger, D., Michelotti, J., Honko, A. N., DeWald, L. E., Bennett, R. S., Olinger, G. G., Jahrling, P. B., & Hensley, L. E. (2017). Interferon-β and interferon-γ are weak inhibitors of ebola virus in cell-based assays. Journal of Infectious Diseases, 215(9), 1416-1420. https://doi.org/10.1093/infdis/jix134

Dyall, J, Hart, BJ, Postnikova, E, Cong, Y, Zhou, H, Gerhardt, DM, Freeburger, D, Michelotti, J, Honko, AN, DeWald, LE, Bennett, RS, Olinger, GG, Jahrling, PB & Hensley, LE 2017, 'Interferon-β and interferon-γ are weak inhibitors of ebola virus in cell-based assays', Journal of Infectious Diseases, vol. 215, no. 9, pp. 1416-1420. https://doi.org/10.1093/infdis/jix134

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title = "Interferon-β and interferon-γ are weak inhibitors of ebola virus in cell-based assays",

abstract = "Previous studies have demonstrated little efficacy of interferons (IFNs) in animal models of Ebola virus disease. However, these studies were limited to a small number of type I IFNs and, during the most recent outbreak of Ebola virus, questions regarding the suitability of the animal models to evaluate IFNs were raised. To address the potential that anti-Ebola virus activity was overlooked, type I and type II IFNs (α-2a, α-2b, -β, -γ, and -universal) were tested in a variety of cell types (Vero E6, Huh 7 cells, and human macrophages). IFNs are weak inhibitors of Ebola virus Makona in these cell lines.",

keywords = "antiviral, Ebola virus, interferon",

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doi = "10.1093/infdis/jix134",

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AU - Zhou, Huanying

AU - Gerhardt, Dawn M.

AU - Freeburger, Denise

AU - Michelotti, Julia

AU - Honko, Anna N.

AU - DeWald, Lisa Evans

AU - Bennett, Richard S.

AU - Olinger, Gene G.

AU - Jahrling, Peter B.

AU - Hensley, Lisa E.

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AB - Previous studies have demonstrated little efficacy of interferons (IFNs) in animal models of Ebola virus disease. However, these studies were limited to a small number of type I IFNs and, during the most recent outbreak of Ebola virus, questions regarding the suitability of the animal models to evaluate IFNs were raised. To address the potential that anti-Ebola virus activity was overlooked, type I and type II IFNs (α-2a, α-2b, -β, -γ, and -universal) were tested in a variety of cell types (Vero E6, Huh 7 cells, and human macrophages). IFNs are weak inhibitors of Ebola virus Makona in these cell lines.

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KW - Ebola virus

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Interferon-β and interferon-γ are weak inhibitors of ebola virus in cell-based assays

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Keywords

ASJC Scopus subject areas

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