Interferon-γ activates the cleavage of double-stranded RNA by bovine seminal ribonuclease

Catherine H. Schein; Monika Haugg; Steven A. Benner

doi:10.1016/0014-5793(90)81275-S

Interferon-γ activates the cleavage of double-stranded RNA by bovine seminal ribonuclease

Catherine H. Schein, Monika Haugg, Steven A. Benner

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Bovine seminal ribonuclease (BS-RNase), a dimeric homologue of RNase A, cleaves both single- and double-stranded RNA and inhibits the growth of tumor cells. Its catalytic activity against double-stranded RNA, either homopolymeric ([³H]polyA/polyU) or mixed sequence, is enhanced by bovine or human recombinant interferon-γ (IFN-γ). Activation is seen with as little as 4-10 interferon units per assay. Enhancing the degradation of double-stranded RNA, an intermediate in the growth cycle of many viruses, could contribute to IFN-γ's ability to control cell growth and induce an antiviral state.

Original language	English (US)
Pages (from-to)	229-232
Number of pages	4
Journal	FEBS Letters
Volume	270
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(90)81275-S
State	Published - Sep 17 1990
Externally published	Yes

Keywords

Activation of double-stranded RNA degradation
Bovine seminal ribonuclease
Interferon-γ Interferon-α
Mechanism of cell growth inhibition by interferons
Ribonuclease A (RNase A)

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(90)81275-S

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title = "Interferon-γ activates the cleavage of double-stranded RNA by bovine seminal ribonuclease",

abstract = "Bovine seminal ribonuclease (BS-RNase), a dimeric homologue of RNase A, cleaves both single- and double-stranded RNA and inhibits the growth of tumor cells. Its catalytic activity against double-stranded RNA, either homopolymeric ([3H]polyA/polyU) or mixed sequence, is enhanced by bovine or human recombinant interferon-γ (IFN-γ). Activation is seen with as little as 4-10 interferon units per assay. Enhancing the degradation of double-stranded RNA, an intermediate in the growth cycle of many viruses, could contribute to IFN-γ's ability to control cell growth and induce an antiviral state.",

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T1 - Interferon-γ activates the cleavage of double-stranded RNA by bovine seminal ribonuclease

AU - Schein, Catherine H.

AU - Haugg, Monika

AU - Benner, Steven A.

PY - 1990/9/17

Y1 - 1990/9/17

N2 - Bovine seminal ribonuclease (BS-RNase), a dimeric homologue of RNase A, cleaves both single- and double-stranded RNA and inhibits the growth of tumor cells. Its catalytic activity against double-stranded RNA, either homopolymeric ([3H]polyA/polyU) or mixed sequence, is enhanced by bovine or human recombinant interferon-γ (IFN-γ). Activation is seen with as little as 4-10 interferon units per assay. Enhancing the degradation of double-stranded RNA, an intermediate in the growth cycle of many viruses, could contribute to IFN-γ's ability to control cell growth and induce an antiviral state.

AB - Bovine seminal ribonuclease (BS-RNase), a dimeric homologue of RNase A, cleaves both single- and double-stranded RNA and inhibits the growth of tumor cells. Its catalytic activity against double-stranded RNA, either homopolymeric ([3H]polyA/polyU) or mixed sequence, is enhanced by bovine or human recombinant interferon-γ (IFN-γ). Activation is seen with as little as 4-10 interferon units per assay. Enhancing the degradation of double-stranded RNA, an intermediate in the growth cycle of many viruses, could contribute to IFN-γ's ability to control cell growth and induce an antiviral state.

KW - Activation of double-stranded RNA degradation

KW - Bovine seminal ribonuclease

KW - Interferon-γ Interferon-α

KW - Mechanism of cell growth inhibition by interferons

KW - Ribonuclease A (RNase A)

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Interferon-γ activates the cleavage of double-stranded RNA by bovine seminal ribonuclease

Abstract

Keywords

ASJC Scopus subject areas

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