Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice

Tian Wang, Mustafa Akkoyunlu, Rila Banerjee, Erol Fikrig

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Immunocompetent mice 129Sv (129) and C57BL/6 (B6) mice are similarly susceptible to Anaplasma phagocytophilum. We now show that 129 mice lacking interferon-γ (IFN-γ) develop more severe infection with A. phagocytophilum than IFN-γ deficient B6 mice. These data demonstrate that there is an inherent increased susceptibility of 129 mice, compared with B6 mice, to A. phagocytophilum that can only be discerned in the absence of IFN-γ.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalFEMS Immunology and Medical Microbiology
Volume42
Issue number3
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

Keywords

  • Animal mode
  • Ehrlichiosis
  • Interferon-γ
  • Tick

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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