Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice

Tian Wang, Mustafa Akkoyunlu, Rila Banerjee, Erol Fikrig

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Immunocompetent mice 129Sv (129) and C57BL/6 (B6) mice are similarly susceptible to Anaplasma phagocytophilum. We now show that 129 mice lacking interferon-γ (IFN-γ) develop more severe infection with A. phagocytophilum than IFN-γ deficient B6 mice. These data demonstrate that there is an inherent increased susceptibility of 129 mice, compared with B6 mice, to A. phagocytophilum that can only be discerned in the absence of IFN-γ.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalFEMS Immunology and Medical Microbiology
Volume42
Issue number3
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

Fingerprint

129 Strain Mouse
Anaplasma phagocytophilum
Inbred C57BL Mouse
Interferons
Infection

Keywords

  • Animal mode
  • Ehrlichiosis
  • Interferon-γ
  • Tick

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases

Cite this

Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice. / Wang, Tian; Akkoyunlu, Mustafa; Banerjee, Rila; Fikrig, Erol.

In: FEMS Immunology and Medical Microbiology, Vol. 42, No. 3, 01.11.2004, p. 299-305.

Research output: Contribution to journalArticle

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