Interferon gamma in leishmaniasis

Peter E. Kima, Lynn Soong

Research output: Contribution to journalShort survey

42 Scopus citations

Abstract

Leishmaniasis is a complex disease that is caused by parasites of the Leishmania genus. Leishmania are further classified into several complexes, each of which can engage in distinct interactions with mammalian hosts resulting in differing disease presentations. It is therefore not unexpected that host immune responses to Leishmania are variable. The induction of interferon gamma (IFN-γ) and response to it in these infections has received considerable attention. In this review, we summarize our current understanding of some of the host responses during Leishmania infections that are regulated by IFN-γ. In addition, studies that explore the nature of parasite-derived molecular mediators that might affect the host response to IFN-γ are also discussed.

Original languageEnglish (US)
Article numberArticle 156
JournalFrontiers in immunology
Volume4
Issue numberJUN
DOIs
StatePublished - 2013

Keywords

  • Chemokines and leishmania
  • Cytokines and leishmania
  • Interferon gamma and Leishmania
  • Leishmania immunology
  • Signal transduction in infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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