Interferon production by human mononuclear leukocytes: Differences between respiratory synctytial virus and influenza viruses

T. Chonmaitree, N. J. Roberts, R. G. Douglas, C. B. Hall, R. L. Simons

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The ability of respiratory syncytial virus (RSV) to induce interferon production by human mononuclear leukocytes was compared with that of influenza viruses. Cell culture fluids were assayed for interferon activity 1, 3, and 7 days after exposure to RSV or to one of two subtypes of influenza A virus (H0N1 and H3N2). RSV induced interferon production inconsistently and in low titers. Varying the multiplicity of infection did not improve the ability of RSV to induce interferon production. In contrast, influenza viruses were effective inducers of interferon production. Seropositivity to the influenza virus strains was not associated with increased interferon titers. Interferon produced after exposure to RSV or to the influenza viruses was resistant to low pH treatment. The data suggest that interferon production may not be a major component of human immunological defense against RSV infection.

Original languageEnglish (US)
Pages (from-to)300-303
Number of pages4
JournalInfection and Immunity
Volume32
Issue number1
StatePublished - 1981
Externally publishedYes

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Mononuclear Leukocytes
Orthomyxoviridae
Interferons
Respiratory Syncytial Viruses
Viruses
Interferon Inducers
H3N2 Subtype Influenza A Virus
Respiratory Syncytial Virus Infections
Cell Culture Techniques
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Chonmaitree, T., Roberts, N. J., Douglas, R. G., Hall, C. B., & Simons, R. L. (1981). Interferon production by human mononuclear leukocytes: Differences between respiratory synctytial virus and influenza viruses. Infection and Immunity, 32(1), 300-303.

Interferon production by human mononuclear leukocytes : Differences between respiratory synctytial virus and influenza viruses. / Chonmaitree, T.; Roberts, N. J.; Douglas, R. G.; Hall, C. B.; Simons, R. L.

In: Infection and Immunity, Vol. 32, No. 1, 1981, p. 300-303.

Research output: Contribution to journalArticle

Chonmaitree, T, Roberts, NJ, Douglas, RG, Hall, CB & Simons, RL 1981, 'Interferon production by human mononuclear leukocytes: Differences between respiratory synctytial virus and influenza viruses', Infection and Immunity, vol. 32, no. 1, pp. 300-303.
Chonmaitree, T. ; Roberts, N. J. ; Douglas, R. G. ; Hall, C. B. ; Simons, R. L. / Interferon production by human mononuclear leukocytes : Differences between respiratory synctytial virus and influenza viruses. In: Infection and Immunity. 1981 ; Vol. 32, No. 1. pp. 300-303.
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