Interferon therapy in primary care

Jeanna M. Piper, Tony T.S. Wen, Elly M.J. Xenakis

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Interferons are proteins produced by human blood cells in response to stimulation (viral infection). The natural roles of interferons are host defense and modulation of the immune system. Therapeutic uses are based on these roles. Interferon-α has been widely used for malignancies, skin conditions, viral infections, and myeloproliferative disorders. Interferon-β is a standard treatment for relapsing multiple sclerosis. Interferon-γ therapy is currently used for chronic granulomatous disease and skin lesions (human papilloma virus related and keloids), but further research is ongoing. Side effects of interferon therapy are common and limit utility. Flulike symptoms are reported by more than 75% and depression by 10-40% of interferon users. Severe adverse effects are less common but may be life threatening, including autoimmune diseases, thrombotic-thrombocytopenic purpura, and acute renal failure. Limited use of interferon therapy during pregnancy has been described, with successful maternal and neonatal outcomes. Use of interferon therapy during early pregnancy is not an indication for termination.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalPrimary Care Update for Ob/Gyns
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2001

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ASJC Scopus subject areas

  • Nursing(all)
  • Obstetrics and Gynecology

Cite this

Piper, J. M., Wen, T. T. S., & Xenakis, E. M. J. (2001). Interferon therapy in primary care. Primary Care Update for Ob/Gyns, 8(4), 163-169. https://doi.org/10.1016/S1068-607X(00)00082-2