Interleukin-1-inhibitor activity induced by respiratory syncytial virus: Abrogation of virus-specific and alternate human lymphocyte proliferative responses

Alan R. Salkind, Donna O. McCarthy, Joan Nichols, Frank M. Domurat, Edward E. Walsh, Norbert J. Roberts

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Respiratory syncytial virus (RSV) infection has been shown to induce human mononuclear leukocyte (MNL) production of net interleukin-1 (IL-1)-inhibitor activity. In the current studies of IL-1-inhibitor effects, RSV-exposed cells were compared with autologous MNL that were shamexposed or exposed to inactivated RSV or influenza virus (which induces net IL-1 activity and commonly elicits effective homotypic immunity). Exposure of MNL to influenza virus or inactivated RSV resulted in increased expression of human leukocyte antigen-DR, the IL-2 receptor, and the transferrin receptor and increased progression through the cell cycle by 3 days. In contrast, exposure to infectious RSV resulted in decreased marker expression and cell cycle arrest, with abrogation of proliferation in response to the virus or other stimuli. These data raise the possibility that a contributing mechanism for recurrence of RSV infection is early suppression of the clonal expansion of virus-specific lymphocytes due to net IL-1-inhibitor activity.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalJournal of Infectious Diseases
Volume163
Issue number1
StatePublished - Jan 1991
Externally publishedYes

Fingerprint

Respiratory Syncytial Viruses
Interleukin-1
Mononuclear Leukocytes
Lymphocytes
Viruses
Respiratory Syncytial Virus Infections
Orthomyxoviridae
Transferrin Receptors
Interleukin-2 Receptors
HLA Antigens
Cell Cycle Checkpoints
Immunity
Cell Cycle
Recurrence

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Interleukin-1-inhibitor activity induced by respiratory syncytial virus : Abrogation of virus-specific and alternate human lymphocyte proliferative responses. / Salkind, Alan R.; McCarthy, Donna O.; Nichols, Joan; Domurat, Frank M.; Walsh, Edward E.; Roberts, Norbert J.

In: Journal of Infectious Diseases, Vol. 163, No. 1, 01.1991, p. 71-77.

Research output: Contribution to journalArticle

Salkind, Alan R. ; McCarthy, Donna O. ; Nichols, Joan ; Domurat, Frank M. ; Walsh, Edward E. ; Roberts, Norbert J. / Interleukin-1-inhibitor activity induced by respiratory syncytial virus : Abrogation of virus-specific and alternate human lymphocyte proliferative responses. In: Journal of Infectious Diseases. 1991 ; Vol. 163, No. 1. pp. 71-77.
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