Interleukin-1-production by monocytes from patients with systemic lupus erythematosus

S. Sierakowski, E. J. Kucharz, R. W. Lightfoot, James Goodwin

Research output: Contribution to journalArticle

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Abstract

Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 μg of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalClinical Rheumatology
Volume6
Issue number3
DOIs
StatePublished - Sep 1987
Externally publishedYes

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Keywords

  • Interleukin-1
  • Monocytes
  • Systemic Lupus Erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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