Abstract
Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 μg of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 403-407 |
| Number of pages | 5 |
| Journal | Clinical Rheumatology |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1987 |
| Externally published | Yes |
Keywords
- Interleukin-1
- Monocytes
- Systemic Lupus Erythematosus
ASJC Scopus subject areas
- Rheumatology
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