Interleukin-2 and autoimmune disease.

N. Talal, M. Dauphinée, P. Christadoss, G. Fernandes, I. J. Russell, N. Miyasaka, T. Nakamura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)239-250
Number of pages12
JournalAdvances in nephrology from the Necker Hospital
Volume12
StatePublished - 1983
Externally publishedYes

Fingerprint

Autoimmune Diseases
Interleukin-2
Autoimmune Experimental Myasthenia Gravis
Inbred Strains Mice
Cholinergic Receptors
Concanavalin A
Mitogens
Systemic Lupus Erythematosus
Genes
Immunization
Blood Cells
Rheumatoid Arthritis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Talal, N., Dauphinée, M., Christadoss, P., Fernandes, G., Russell, I. J., Miyasaka, N., & Nakamura, T. (1983). Interleukin-2 and autoimmune disease. Advances in nephrology from the Necker Hospital, 12, 239-250.

Interleukin-2 and autoimmune disease. / Talal, N.; Dauphinée, M.; Christadoss, P.; Fernandes, G.; Russell, I. J.; Miyasaka, N.; Nakamura, T.

In: Advances in nephrology from the Necker Hospital, Vol. 12, 1983, p. 239-250.

Research output: Contribution to journalArticle

Talal, N, Dauphinée, M, Christadoss, P, Fernandes, G, Russell, IJ, Miyasaka, N & Nakamura, T 1983, 'Interleukin-2 and autoimmune disease.', Advances in nephrology from the Necker Hospital, vol. 12, pp. 239-250.
Talal N, Dauphinée M, Christadoss P, Fernandes G, Russell IJ, Miyasaka N et al. Interleukin-2 and autoimmune disease. Advances in nephrology from the Necker Hospital. 1983;12:239-250.
Talal, N. ; Dauphinée, M. ; Christadoss, P. ; Fernandes, G. ; Russell, I. J. ; Miyasaka, N. ; Nakamura, T. / Interleukin-2 and autoimmune disease. In: Advances in nephrology from the Necker Hospital. 1983 ; Vol. 12. pp. 239-250.
@article{d91e77c9f28645278133561953037f44,
title = "Interleukin-2 and autoimmune disease.",
abstract = "Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.",
author = "N. Talal and M. Dauphin{\'e}e and P. Christadoss and G. Fernandes and Russell, {I. J.} and N. Miyasaka and T. Nakamura",
year = "1983",
language = "English (US)",
volume = "12",
pages = "239--250",
journal = "Advances in nephrology from the Necker Hospital",
issn = "0084-5957",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Interleukin-2 and autoimmune disease.

AU - Talal, N.

AU - Dauphinée, M.

AU - Christadoss, P.

AU - Fernandes, G.

AU - Russell, I. J.

AU - Miyasaka, N.

AU - Nakamura, T.

PY - 1983

Y1 - 1983

N2 - Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.

AB - Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.

UR - http://www.scopus.com/inward/record.url?scp=0020687621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020687621&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 239

EP - 250

JO - Advances in nephrology from the Necker Hospital

JF - Advances in nephrology from the Necker Hospital

SN - 0084-5957

ER -