Abstract
Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 239-250 |
| Number of pages | 12 |
| Journal | Advances in nephrology from the Necker Hospital |
| Volume | 12 |
| State | Published - 1983 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Medicine