Interleukin-2 and autoimmune disease.

N. Talal; M. Dauphinée; P. Christadoss; G. Fernandes; I. J. Russell; N. Miyasaka; T. Nakamura

Interleukin-2 and autoimmune disease.

N. Talal, M. Dauphinée, P. Christadoss, G. Fernandes, I. J. Russell, N. Miyasaka, T. Nakamura

Research output: Contribution to journal › Article › peer-review

Abstract

Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.

Original language	English (US)
Pages (from-to)	239-250
Number of pages	12
Journal	Advances in nephrology from the Necker Hospital
Volume	12
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Interleukin-2 and autoimmune disease.",

abstract = "Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.",

author = "N. Talal and M. Dauphin{\'e}e and P. Christadoss and G. Fernandes and Russell, \{I. J.\} and N. Miyasaka and T. Nakamura",

year = "1983",

language = "English (US)",

volume = "12",

pages = "239--250",

journal = "Advances in nephrology from the Necker Hospital",

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T1 - Interleukin-2 and autoimmune disease.

AU - Talal, N.

AU - Dauphinée, M.

AU - Christadoss, P.

AU - Fernandes, G.

AU - Russell, I. J.

AU - Miyasaka, N.

AU - Nakamura, T.

PY - 1983

Y1 - 1983

N2 - Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.

AB - Interleukin-2 (IL-2) deficiency is a common feature of autoimmune disease in several inbred strains of mice genetically predisposed to a lupus-like illness, including four (MRL, C57Bl/6, AKR/J, and C3H/He) bearing the lpr gene. Defective production of IL-2 in response to concanavalin A can occur even when the proliferative response to mitogens is preserved. In C56Bl/6-lpr mice there is no apparent influence of the lpr gene and IL-2 deficiency on the induction of the experimental autoimmune myasthenia gravis that follows immunization with the acetylcholine receptor. The production of IL-2 by peripheral blood mononuclear cells stimulated with PHA is decreased in patients with systemic lupus erythematosus and rheumatoid arthritis.

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M3 - Article

C2 - 6404137

AN - SCOPUS:0020687621

SN - 0084-5957

VL - 12

SP - 239

EP - 250

JO - Advances in nephrology from the Necker Hospital

JF - Advances in nephrology from the Necker Hospital

ER -

Interleukin-2 and autoimmune disease.

Abstract

ASJC Scopus subject areas

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