Interleukin-2 increases CD4+ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s

Hernan Valdez, Ronald Mitsuyasu, Alan Landay, Anne D. Sevin, Ellen S. Chan, John Spritzler, Spyros A. Kalams, Richard B. Pollard, John Fahey, Lawrence Fox, Ann Namkung, Scharla Estep, Ronald Moss, David Sahner, Michael M. Lederman

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

To ascertain whether CD4+ lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4+ lymphocyte counts, IL-2 did not enhance immunization responses.

Original languageEnglish (US)
Pages (from-to)320-325
Number of pages6
JournalJournal of Infectious Diseases
Volume187
Issue number2
DOIs
StatePublished - Jan 15 2003
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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