Interleukin-2 increases CD4+ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s

Hernan Valdez; Ronald Mitsuyasu; Alan Landay; Anne D. Sevin; Ellen S. Chan; John Spritzler; Spyros A. Kalams; Richard B. Pollard; John Fahey; Lawrence Fox; Ann Namkung; Scharla Estep; Ronald Moss; David Sahner; Michael M. Lederman

doi:10.1086/346056

Interleukin-2 increases CD4⁺ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s

Hernan Valdez
, Ronald Mitsuyasu
, Alan Landay
, Anne D. Sevin
, Ellen S. Chan
, John Spritzler
, Spyros A. Kalams
, Richard B. Pollard
, John Fahey
, Lawrence Fox
, Ann Namkung
, Scharla Estep
, Ronald Moss
, David Sahner
, Michael M. Lederman

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

To ascertain whether CD4⁺ lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4⁺ lymphocyte counts, IL-2 did not enhance immunization responses.

Original language	English (US)
Pages (from-to)	320-325
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	187
Issue number	2
DOIs	https://doi.org/10.1086/346056
State	Published - Jan 15 2003
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1086/346056

Cite this

Valdez, H., Mitsuyasu, R., Landay, A., Sevin, A. D., Chan, E. S., Spritzler, J., Kalams, S. A., Pollard, R. B., Fahey, J., Fox, L., Namkung, A., Estep, S., Moss, R., Sahner, D., & Lederman, M. M. (2003). Interleukin-2 increases CD4⁺ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s. Journal of Infectious Diseases, 187(2), 320-325. https://doi.org/10.1086/346056

Valdez, H, Mitsuyasu, R, Landay, A, Sevin, AD, Chan, ES, Spritzler, J, Kalams, SA, Pollard, RB, Fahey, J, Fox, L, Namkung, A, Estep, S, Moss, R, Sahner, D & Lederman, MM 2003, 'Interleukin-2 increases CD4⁺ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s', Journal of Infectious Diseases, vol. 187, no. 2, pp. 320-325. https://doi.org/10.1086/346056

@article{17a3d4ee27da4e40b6e91c8965028469,

title = "Interleukin-2 increases CD4+ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s",

abstract = "To ascertain whether CD4+ lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4+ lymphocyte counts, IL-2 did not enhance immunization responses.",

author = "Hernan Valdez and Ronald Mitsuyasu and Alan Landay and Sevin, \{Anne D.\} and Chan, \{Ellen S.\} and John Spritzler and Kalams, \{Spyros A.\} and Pollard, \{Richard B.\} and John Fahey and Lawrence Fox and Ann Namkung and Scharla Estep and Ronald Moss and David Sahner and Lederman, \{Michael M.\}",

year = "2003",

month = jan,

day = "15",

doi = "10.1086/346056",

language = "English (US)",

volume = "187",

pages = "320--325",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Interleukin-2 increases CD4+ lymphocyte numbers but does not enhance responses to immunization

T2 - Results of A5046s

AU - Valdez, Hernan

AU - Mitsuyasu, Ronald

AU - Landay, Alan

AU - Sevin, Anne D.

AU - Chan, Ellen S.

AU - Spritzler, John

AU - Kalams, Spyros A.

AU - Pollard, Richard B.

AU - Fahey, John

AU - Fox, Lawrence

AU - Namkung, Ann

AU - Estep, Scharla

AU - Moss, Ronald

AU - Sahner, David

AU - Lederman, Michael M.

PY - 2003/1/15

Y1 - 2003/1/15

N2 - To ascertain whether CD4+ lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4+ lymphocyte counts, IL-2 did not enhance immunization responses.

AB - To ascertain whether CD4+ lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4+ lymphocyte counts, IL-2 did not enhance immunization responses.

UR - https://www.scopus.com/pages/publications/0037439282

UR - https://www.scopus.com/pages/publications/0037439282#tab=citedBy

U2 - 10.1086/346056

DO - 10.1086/346056

M3 - Article

C2 - 12552459

AN - SCOPUS:0037439282

SN - 0022-1899

VL - 187

SP - 320

EP - 325

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 2

ER -

Interleukin-2 increases CD4⁺ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this