Interleukin-6 response to laparoscopic and open colectomy

Gary D. Harmon, Anthony J. Senagore, Michael J. Kilbride, Michael J. Warzynski

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

PURPOSE: It has been postulated that cortisol and interleukin-6 play a significant role in the modulation of the early inflammatory response following surgical intervention. There are no available data on the normal responses of these mediators following major laparoscopic procedures. The purpose of this study was to assess changes in cortisol (by fluorescence polarization immunoassay), interleukin-6 (by enzyme-linked immunoassay), and interleukin-1 (by enzyme-linked immunoassay) after elective laparoscopic colon resections. METHODS: All patients undergoing colon resection between February 1, 1992 and April 30, 1992 were eligible for study. Selection of laparoscopic (N=12)vs. open (N=41) resection was determined by the attending surgeon. All patients received a standard general anesthetic with endotracheal intubation. Cortisol, interleukin-6, and interleukin-1 were measured at preinduction, 1 hour, 2 hours, 3 hours, 4 hours, and 5 hours after the induction. Interleukin-6 and interleukin-1 were additionally measured at 12 hours, 24 hours, and 72 hours after induction. Comparisons were made between the laparoscopic patients (N=12) and age, sex, and operation-matched open patients (N=12). RESULTS: Cortisol levels rose in the early postoperative period in both open and laparoscopic groups with no significant differences occurring between the cohorts at any of the measured time intervals. The interleukin-6 levels of the laparoscopic cohort (N=12) were significantly lower than those of the open cohort (N=12) between 3 and 24 hours postinduction (P

Original languageEnglish (US)
Pages (from-to)754-759
Number of pages6
JournalDiseases of the Colon and Rectum
Volume37
Issue number8
DOIs
StatePublished - Aug 1994
Externally publishedYes

Fingerprint

Colectomy
Interleukin-6
Hydrocortisone
Interleukin-1
Immunoenzyme Techniques
Colon
Fluorescence Polarization Immunoassay
General Anesthetics
Intratracheal Intubation
Postoperative Period

Keywords

  • Cortisol
  • Interleukin-1
  • Interleukin-6
  • Laparoscopic colectomy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Harmon, G. D., Senagore, A. J., Kilbride, M. J., & Warzynski, M. J. (1994). Interleukin-6 response to laparoscopic and open colectomy. Diseases of the Colon and Rectum, 37(8), 754-759. https://doi.org/10.1007/BF02050137

Interleukin-6 response to laparoscopic and open colectomy. / Harmon, Gary D.; Senagore, Anthony J.; Kilbride, Michael J.; Warzynski, Michael J.

In: Diseases of the Colon and Rectum, Vol. 37, No. 8, 08.1994, p. 754-759.

Research output: Contribution to journalArticle

Harmon, GD, Senagore, AJ, Kilbride, MJ & Warzynski, MJ 1994, 'Interleukin-6 response to laparoscopic and open colectomy', Diseases of the Colon and Rectum, vol. 37, no. 8, pp. 754-759. https://doi.org/10.1007/BF02050137
Harmon, Gary D. ; Senagore, Anthony J. ; Kilbride, Michael J. ; Warzynski, Michael J. / Interleukin-6 response to laparoscopic and open colectomy. In: Diseases of the Colon and Rectum. 1994 ; Vol. 37, No. 8. pp. 754-759.
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