Interleukin-6 response to laparoscopic and open colectomy

Gary D. Harmon, Anthony J. Senagore, Michael J. Kilbride, Michael J. Warzynski

    Research output: Contribution to journalArticle

    140 Scopus citations

    Abstract

    PURPOSE: It has been postulated that cortisol and interleukin-6 play a significant role in the modulation of the early inflammatory response following surgical intervention. There are no available data on the normal responses of these mediators following major laparoscopic procedures. The purpose of this study was to assess changes in cortisol (by fluorescence polarization immunoassay), interleukin-6 (by enzyme-linked immunoassay), and interleukin-1 (by enzyme-linked immunoassay) after elective laparoscopic colon resections. METHODS: All patients undergoing colon resection between February 1, 1992 and April 30, 1992 were eligible for study. Selection of laparoscopic (N=12) vs. open (N=41) resection was determined by the attending surgeon. All patients received a standard general anesthetic with endotracheal intubation. Cortisol, interleukin-6, and interleukin-1 were measured at preinduction, 1 hour, 2 hours, 3 hours, 4 hours, and 5 hours after the induction. Interleukin-6 and interleukin-1 were additionally measured at 12 hours, 24 hours, and 72 hours after induction. Comparisons were made between the laparoscopic patients (N=12) and age, sex, and operation-matched open patients (N=12). RESULTS: Cortisol levels rose in the early postoperative period in both open and laparoscopic groups with no significant differences occurring between the cohorts at any of the measured time intervals. The interleukin-6 levels of the laparoscopic cohort (N=12) were significantly lower than those of the open cohort (N=12) between 3 and 24 hours postinduction (P<0.05). Interleukin-1 levels remained undetectable in virtually all patients irrespective of operative technique or postoperative interval. There was no correlation between peak interleukin-6 levels and operative times (laparoscopic, r=0.31; open, r=0.36) or blood loss (laparoscopic, r=0.10; open, r=0.20). CONCLUSION: The results indicate that laparoscopic colon resections do not appear to alter cortisol or interleukin-1 responses when compared with open colon resection. There is, however, a significant blunting of the interleukin-6 response associated with the use of laparoscopic techniques for colectomy compared with standard laparotomy.

    Original languageEnglish (US)
    Pages (from-to)754-759
    Number of pages6
    JournalDiseases of the Colon & Rectum
    Volume37
    Issue number8
    DOIs
    StatePublished - Aug 1 1994

    Keywords

    • Cortisol
    • Interleukin-1
    • Interleukin-6
    • Laparoscopic colectomy

    ASJC Scopus subject areas

    • Gastroenterology

    Fingerprint Dive into the research topics of 'Interleukin-6 response to laparoscopic and open colectomy'. Together they form a unique fingerprint.

  • Cite this

    Harmon, G. D., Senagore, A. J., Kilbride, M. J., & Warzynski, M. J. (1994). Interleukin-6 response to laparoscopic and open colectomy. Diseases of the Colon & Rectum, 37(8), 754-759. https://doi.org/10.1007/BF02050137