Interleukin 8 and acute lung injury

Timothy Craig Allen, Anna Kurdowska

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Acute lung injury is a complex clinical syndrome involving acute inflammation, microvascular damage, and increased pulmonary vascular and epithelial permeability, frequently resulting in acute respiratory failure culminating in often-fatal acute respiratory distress syndrome. Interleukin 8 (IL-8), a potent neutrophil attractant and activator, plays a significant role in acute lung injury via the formation of anti-IL-8 autoantibody:IL-8 complexes and those complexes' interaction with FccRIIa receptors, leading to the development of acute lung injury by, among other possible mechanisms, effecting neutrophil apoptosis. These complexes may also interact with lung endothelial cells in patients with acute respiratory distress syndrome. Continuing research of the role of neutrophils, IL-8, anti- IL-8 autoantibody:IL-8 complexes, and FccRIIa receptors may ultimately provide molecular therapies that could lower acute respiratory distress syndrome mortality, as well as reduce or even prevent the development of acute lung injury altogether.

Original languageEnglish (US)
Pages (from-to)266-269
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume138
Issue number2
DOIs
StatePublished - Feb 2014

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Acute Lung Injury
Interleukin-8
Adult Respiratory Distress Syndrome
Neutrophils
Autoantibodies
Lung
Capillary Permeability
Respiratory Insufficiency
Endothelial Cells
Apoptosis
Inflammation
Mortality
Research

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Interleukin 8 and acute lung injury. / Allen, Timothy Craig; Kurdowska, Anna.

In: Archives of Pathology and Laboratory Medicine, Vol. 138, No. 2, 02.2014, p. 266-269.

Research output: Contribution to journalArticle

Allen, Timothy Craig ; Kurdowska, Anna. / Interleukin 8 and acute lung injury. In: Archives of Pathology and Laboratory Medicine. 2014 ; Vol. 138, No. 2. pp. 266-269.
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