Interleukin-8, tumor necrosis factor-α, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis

Cirle S. Alcantara, Chang Hun Yang, Theodore S. Steiner, Leah J. Barrett, Aldo A M Lima, Cynthia L. Chappell, Pablo C. Okhuysen, A. Clinton White, Richard L. Guerrant

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

To examine the importance of intestinal inflammation in the diagnosis and pathogenesis of human cryptosporidiosis, stools of healthy adult volunteers before and after experimental infection were tested for fecal lactoferrin, interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α). Stool samples of Brazilian children with well-defined Cryptosporidium infection, with or without diarrhea, were also tested for IL-8 and TNF-α Only one of the 14 volunteers challenged with Cryptosporidium had increased fecal lactoferrin. However, of 17 stool specimens from children with only Cryptosporidium infection from a previous study, 12 had mild to moderately elevated lactoferrin despite negative work-up for inflammatory enteritides. One of 10 adult volunteers who developed diarrhea with experimental cryptosporidiosis and three of 11 children with cryptosporidiosis and diarrhea had detectable fecal IL-8. The level of TNF-α was increased only in one of 14 volunteers and in none of the children. Although considered relatively non-inflammatory, cryptosporidiosis is often associated with mild inflammation, especially in children in an endemic area.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume68
Issue number3
StatePublished - Mar 2003
Externally publishedYes

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Cryptosporidiosis
Lactoferrin
Interleukin-8
Tumor Necrosis Factor-alpha
Cryptosporidium
Volunteers
Diarrhea
Infection
Inflammation
Enteritis
Healthy Volunteers

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Alcantara, C. S., Yang, C. H., Steiner, T. S., Barrett, L. J., Lima, A. A. M., Chappell, C. L., ... Guerrant, R. L. (2003). Interleukin-8, tumor necrosis factor-α, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. American Journal of Tropical Medicine and Hygiene, 68(3), 325-328.

Interleukin-8, tumor necrosis factor-α, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. / Alcantara, Cirle S.; Yang, Chang Hun; Steiner, Theodore S.; Barrett, Leah J.; Lima, Aldo A M; Chappell, Cynthia L.; Okhuysen, Pablo C.; White, A. Clinton; Guerrant, Richard L.

In: American Journal of Tropical Medicine and Hygiene, Vol. 68, No. 3, 03.2003, p. 325-328.

Research output: Contribution to journalArticle

Alcantara, CS, Yang, CH, Steiner, TS, Barrett, LJ, Lima, AAM, Chappell, CL, Okhuysen, PC, White, AC & Guerrant, RL 2003, 'Interleukin-8, tumor necrosis factor-α, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis', American Journal of Tropical Medicine and Hygiene, vol. 68, no. 3, pp. 325-328.
Alcantara, Cirle S. ; Yang, Chang Hun ; Steiner, Theodore S. ; Barrett, Leah J. ; Lima, Aldo A M ; Chappell, Cynthia L. ; Okhuysen, Pablo C. ; White, A. Clinton ; Guerrant, Richard L. / Interleukin-8, tumor necrosis factor-α, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. In: American Journal of Tropical Medicine and Hygiene. 2003 ; Vol. 68, No. 3. pp. 325-328.
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