International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function

Nicholas M. Barnes; Gerard P. Ahern; Carine Becamel; Joël Bockaert; Michael Camilleri; Severine Chaumont-Dubel; Sylvie Claeysen; Kathryn A. Cunningham; Kevin C. Fone; Michael Gershon; Giuseppe Di Giovanni; Nathalie M. Goodfellow; Adam L. Halberstadt; Rachel Hartley; Ghérici Hassaine; Katharine Herrick-Davis; Ruud Hovius; Enza Lacivita; Evelyn K. Lambe; Marcello Leopoldo; Finn Olav Levy; Sarah C.R. Lummis; Philippe Marin; Luc Maroteaux; Andrew C. McCreary; David L. Nelson; John F. Neumaier; Adrian Newman-Tancredi; Hugues Nury; Alexander Roberts; Bryan L. Roth; Anne Roumier; Gareth J. Sanger; Milt Teitler; Trevor Sharp; Carlos M. Villalón; Horst Vogel; Stephanie W. Watts; Daniel Hoyer

doi:10.1124/PR.118.015552

International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function

Nicholas M. Barnes, Gerard P. Ahern, Carine Becamel, Joël Bockaert, Michael Camilleri, Severine Chaumont-Dubel, Sylvie Claeysen, Kathryn A. Cunningham, Kevin C. Fone, Michael Gershon, Giuseppe Di Giovanni, Nathalie M. Goodfellow, Adam L. Halberstadt, Rachel Hartley, Ghérici Hassaine, Katharine Herrick-Davis, Ruud Hovius, Enza Lacivita, Evelyn K. Lambe, Marcello LeopoldoFinn Olav Levy, Sarah C.R. Lummis, Philippe Marin, Luc Maroteaux, Andrew C. McCreary, David L. Nelson, John F. Neumaier, Adrian Newman-Tancredi, Hugues Nury, Alexander Roberts, Bryan L. Roth, Anne Roumier, Gareth J. Sanger, Milt Teitler, Trevor Sharp, Carlos M. Villalón, Horst Vogel, Stephanie W. Watts, Daniel Hoyer

Pharmacology & Toxicology

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors.

Original language	English (US)
Pages (from-to)	310-520
Number of pages	211
Journal	Pharmacological reviews
Volume	73
Issue number	1
DOIs	https://doi.org/10.1124/PR.118.015552
State	Published - Jan 2021

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1124/PR.118.015552

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Barnes, N. M., Ahern, G. P., Becamel, C., Bockaert, J., Camilleri, M., Chaumont-Dubel, S., Claeysen, S., Cunningham, K. A., Fone, K. C., Gershon, M., Di Giovanni, G., Goodfellow, N. M., Halberstadt, A. L., Hartley, R., Hassaine, G., Herrick-Davis, K., Hovius, R., Lacivita, E., Lambe, E. K., ... Hoyer, D. (2021). International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function. Pharmacological reviews, 73(1), 310-520. https://doi.org/10.1124/PR.118.015552

Barnes, NM, Ahern, GP, Becamel, C, Bockaert, J, Camilleri, M, Chaumont-Dubel, S, Claeysen, S, Cunningham, KA, Fone, KC, Gershon, M, Di Giovanni, G, Goodfellow, NM, Halberstadt, AL, Hartley, R, Hassaine, G, Herrick-Davis, K, Hovius, R, Lacivita, E, Lambe, EK, Leopoldo, M, Levy, FO, Lummis, SCR, Marin, P, Maroteaux, L, McCreary, AC, Nelson, DL, Neumaier, JF, Newman-Tancredi, A, Nury, H, Roberts, A, Roth, BL, Roumier, A, Sanger, GJ, Teitler, M, Sharp, T, Villalón, CM, Vogel, H, Watts, SW & Hoyer, D 2021, 'International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function', Pharmacological reviews, vol. 73, no. 1, pp. 310-520. https://doi.org/10.1124/PR.118.015552

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abstract = "5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors.",

author = "Barnes, {Nicholas M.} and Ahern, {Gerard P.} and Carine Becamel and Jo{\"e}l Bockaert and Michael Camilleri and Severine Chaumont-Dubel and Sylvie Claeysen and Cunningham, {Kathryn A.} and Fone, {Kevin C.} and Michael Gershon and {Di Giovanni}, Giuseppe and Goodfellow, {Nathalie M.} and Halberstadt, {Adam L.} and Rachel Hartley and Gh{\'e}rici Hassaine and Katharine Herrick-Davis and Ruud Hovius and Enza Lacivita and Lambe, {Evelyn K.} and Marcello Leopoldo and Levy, {Finn Olav} and Lummis, {Sarah C.R.} and Philippe Marin and Luc Maroteaux and McCreary, {Andrew C.} and Nelson, {David L.} and Neumaier, {John F.} and Adrian Newman-Tancredi and Hugues Nury and Alexander Roberts and Roth, {Bryan L.} and Anne Roumier and Sanger, {Gareth J.} and Milt Teitler and Trevor Sharp and Villal{\'o}n, {Carlos M.} and Horst Vogel and Watts, {Stephanie W.} and Daniel Hoyer",

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year = "2021",

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doi = "10.1124/PR.118.015552",

language = "English (US)",

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AU - Bockaert, Joël

AU - Camilleri, Michael

AU - Chaumont-Dubel, Severine

AU - Claeysen, Sylvie

AU - Cunningham, Kathryn A.

AU - Fone, Kevin C.

AU - Gershon, Michael

AU - Di Giovanni, Giuseppe

AU - Goodfellow, Nathalie M.

AU - Halberstadt, Adam L.

AU - Hartley, Rachel

AU - Hassaine, Ghérici

AU - Herrick-Davis, Katharine

AU - Hovius, Ruud

AU - Lacivita, Enza

AU - Lambe, Evelyn K.

AU - Leopoldo, Marcello

AU - Levy, Finn Olav

AU - Lummis, Sarah C.R.

AU - Marin, Philippe

AU - Maroteaux, Luc

AU - McCreary, Andrew C.

AU - Nelson, David L.

AU - Neumaier, John F.

AU - Newman-Tancredi, Adrian

AU - Nury, Hugues

AU - Roberts, Alexander

AU - Roth, Bryan L.

AU - Roumier, Anne

AU - Sanger, Gareth J.

AU - Teitler, Milt

AU - Sharp, Trevor

AU - Villalón, Carlos M.

AU - Vogel, Horst

AU - Watts, Stephanie W.

AU - Hoyer, Daniel

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International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function

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