Interplay of stress and physical inactivity on muscle loss: Nutritional countermeasures

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Inactivity-mediated protein catabolism occurs in many circumstances ranging from catastrophic events such as severe illness or injury, to unique environments such as spaceflight/microgravity, to more insidious causes such as physical frailty and the progression of aging. Nevertheless, regardless of the etiology, the consequences of inactivity are readily observable and debilitating. Mechanistically, the loss of lean body mass during inactivity is the result of a chronic imbalance between muscle protein synthesis and breakdown. When inactivity is accompanied by the stress of trauma or disease, the rate of muscle protein catabolism can increase several fold. Bed rest studies in healthy volunteers provide a unique opportunity to examine the mechanisms contributing to muscle loss and evaluate strategies for intervention that may slow muscle catabolism and promote anabolism. The prerequisite for muscle protein synthesis and the most readily adaptable stimulus is dietary-derived amino acids. This review focuses on the role of amino acid supplementation in the maintenance of skeletal muscle mass during age-related and clinically mandated inactivity.

Original languageEnglish (US)
Pages (from-to)2123-2126
Number of pages4
JournalJournal of Nutrition
Volume136
Issue number8
StatePublished - 2006

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muscle protein
Muscle Proteins
protein metabolism
Muscles
muscles
protein synthesis
space flight
microgravity
amino acids
metabolism
lean body mass
Amino Acids
Weightlessness
Space Flight
Bed Rest
volunteers
etiology
skeletal muscle
Wounds and Injuries
Healthy Volunteers

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Interplay of stress and physical inactivity on muscle loss : Nutritional countermeasures. / Paddon-Jones, Douglas.

In: Journal of Nutrition, Vol. 136, No. 8, 2006, p. 2123-2126.

Research output: Contribution to journalArticle

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