Interrelationship between the early inflammatory response and subsequent fibrosis after radiation exposure

R. L. Ullrich, G. W. Casarett

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The mechanistic relation between the early inflammatory response and subsequent fibrosis seen after radiation exposure were studied in rats given X-ray doses of either 2000 or 5000 rad to standardized fields of the inner thigh. The animals were further subdivided into those receiving no additional treatment and those depleted of complement with cobra-venom factor. The results are consistent with the hypothesis that two mechanisms are responsible for the increases in extravasation rate and vascular injury seen after irradiation. First, direct cytocidal damage; second, chemically mediated, possibly complement-dependent, mechanisms. In addition, these data suggest that both direct and indirect damage to the vasculature play a role in influencing the subsequent late-radiation-induced fibrosis.

Original languageEnglish (US)
Pages (from-to)107-121
Number of pages15
JournalRadiation research
Volume72
Issue number1
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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