Interrelationships between the thyroid gland and gastrin secretion: Effects of triiodothyronine and thyroidectomy

Masaki Fujimura, George H. Greeley, Felix Lluis, James C. Thompson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The effects of alterations in thyroid hormone status on secretion of gastrin in the adult rat and dog were studied to better understand previously reported changes in gastric secretion following hypophysectomy. Administration of triiodothyronine (T3) increased serum levels of gastrin in fed rats and both basal and fed gastrin levels in dogs. In T3-treated rats, antral gastrin and somatostatin levels were reduced significantly (P<0.05), whereas gastrin-releasing peptide (GRP) levels were increased. These data suggest that T3-treatment increases gastrin release by reducing antral concentrations of somatostatin and increasing antral concentrations of gastrinreleasing peptide, two peptides that are thought to participate in the regulation of gastrin secretion. Thyroidectomy significantly (P<0.05) decreased the serum gastrin response to food ingestion but did not affect basal levels ofgastrin in fasted rats. Thyroidectomy also significantly decreased serum levels of gastrin stimulated by gastrin-releasing peptide in fed rats.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalBiomedical Research (Japan)
Issue number1
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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