Interrelationships between the thyroid gland and gastrin secretion

Effects of triiodothyronine and thyroidectomy

M. Fujimura, G. H. Greeley, F. Lluis, J. C. Thompson

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    The effects of alterations in thyroid hormone status on secretion of gastrin in the adult rat and dog were studied to better understand previously reported changes in gastric secretion following hypophysectomy. Administration of triiodothyronine (T3) increased serum levels of gastrin in fed rats and both basal and fed gastrin levels in dogs. In T3-treated rats, antral gastrin and somatostatin levels were reduced significantly (P < 0.05), whereas gastrin-releasing peptide (GRP) levels were increased. These data suggest that T3-treatment increases gastrin release by reducing antral concentrations of somatostatin and increasing antral concentrations of gastrin-releasing peptide, two peptides that are thought to participate in the regulation of gastrin secretion. Thyroidectomy significantly (P < 0.05) decreased the serum gastrin response to food ingestion but did not affect basal levels of gastrin in fasted rats. Thyroidectomy also significantly decreased serum levels of gastrin stimulated by gastrin releasing peptide in fed rats.

    Original languageEnglish (US)
    Pages (from-to)55-59
    Number of pages5
    JournalBiomedical Research
    Volume11
    Issue number1
    StatePublished - 1990

    Fingerprint

    Thyroidectomy
    Gastrins
    Triiodothyronine
    Thyroid Gland
    Rats
    Gastrin-Releasing Peptide
    Somatostatin
    Serum
    Dogs
    Hypophysectomy
    Thyroid Hormones
    Stomach
    Eating
    Food
    Peptides

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Interrelationships between the thyroid gland and gastrin secretion : Effects of triiodothyronine and thyroidectomy. / Fujimura, M.; Greeley, G. H.; Lluis, F.; Thompson, J. C.

    In: Biomedical Research, Vol. 11, No. 1, 1990, p. 55-59.

    Research output: Contribution to journalArticle

    Fujimura, M, Greeley, GH, Lluis, F & Thompson, JC 1990, 'Interrelationships between the thyroid gland and gastrin secretion: Effects of triiodothyronine and thyroidectomy', Biomedical Research, vol. 11, no. 1, pp. 55-59.
    Fujimura, M. ; Greeley, G. H. ; Lluis, F. ; Thompson, J. C. / Interrelationships between the thyroid gland and gastrin secretion : Effects of triiodothyronine and thyroidectomy. In: Biomedical Research. 1990 ; Vol. 11, No. 1. pp. 55-59.
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