Intestinal immune response to human Cryptosporidium sp. infection

Birte Pantenburg, Sara Dann-Grice, Heuy Ching Wang, Prema Robinson, Alejandro Castellanos, Dorothy E. Lewis, A. Clinton White

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Immunity to Cryptosporidium involves both innate and adaptive immune responses. Initially, chemokines such as CXCL-10 and perhaps CXCL-8 attract effector cells to the site of infection. Activation of an early immune response by IL-15 is critical for initial clearance of the parasite. CD4+ T cells and IFN-γ play key roles in the human memory response. The function of B cells and CD8+ T cells requires further research. The intestinal inflammatory response seems to mediate diarrhea. Substance P is likely a key mediator of gastrointestinal symptoms in human infection; prostaglandins have been implicated in animal models, but their role in human infection is unclear. TGF-β and IL-10 are likely involved in anti-inflammatory and healing processes. They may also lead to generation of secretory IgA, which may prevent reinfection. Despite the difficulties of investigating human intestinal immune responses, such studies provide important insights into the human mucosal immune response. Since cryptosporidiosis has a significant impact on the health of immunocompromised patients and children in developing countries, further study of the pathogenesis and host immune response in patients with cryptosporidiosis is warranted. Cryptosporidium infection may also provide an important model for dissecting the human intestinal mucosal immune response towards other pathogens and for studying aberrant responses in inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalInfection and Immunity
Volume76
Issue number1
DOIs
StatePublished - Jan 2008

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Cryptosporidium
Infection
Cryptosporidiosis
Mucosal Immunity
T-Lymphocytes
Secretory Immunoglobulin A
Interleukin-15
Immunocompromised Host
Adaptive Immunity
Substance P
Inflammatory Bowel Diseases
Chemokines
Innate Immunity
Interleukin-10
Developing Countries
Prostaglandins
Diarrhea
Immunity
Parasites
B-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Intestinal immune response to human Cryptosporidium sp. infection. / Pantenburg, Birte; Dann-Grice, Sara; Wang, Heuy Ching; Robinson, Prema; Castellanos, Alejandro; Lewis, Dorothy E.; White, A. Clinton.

In: Infection and Immunity, Vol. 76, No. 1, 01.2008, p. 23-29.

Research output: Contribution to journalArticle

Pantenburg, Birte ; Dann-Grice, Sara ; Wang, Heuy Ching ; Robinson, Prema ; Castellanos, Alejandro ; Lewis, Dorothy E. ; White, A. Clinton. / Intestinal immune response to human Cryptosporidium sp. infection. In: Infection and Immunity. 2008 ; Vol. 76, No. 1. pp. 23-29.
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