Intestinal myofibroblasts and immune tolerance

J. I. Saada; C. A. Barrera; V. E. Reyes; P. A. Adegboyega; G. Suarez; R. A. Tamerisa; K. F. Pang; D. A. Bland; R. C. Mifflin; J. F. Di Mari; D. W. Powell

doi:10.1196/annals.1309.023

Intestinal myofibroblasts and immune tolerance

J. I. Saada, C. A. Barrera, V. E. Reyes, P. A. Adegboyega, G. Suarez, R. A. Tamerisa, K. F. Pang, D. A. Bland, R. C. Mifflin, J. F. Di Mari, D. W. Powell

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4⁺ T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.

Original language	English (US)
Pages (from-to)	379-381
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1029
DOIs	https://doi.org/10.1196/annals.1309.023
State	Published - 2004

Keywords

Antigen-presenting cell
Fibroblastic sheath
HLA-DR
Immune tolerance
Mucosal immunity

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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title = "Intestinal myofibroblasts and immune tolerance",

abstract = "Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4+ T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.",

keywords = "Antigen-presenting cell, Fibroblastic sheath, HLA-DR, Immune tolerance, Mucosal immunity",

author = "Saada, {J. I.} and Barrera, {C. A.} and Reyes, {V. E.} and Adegboyega, {P. A.} and G. Suarez and Tamerisa, {R. A.} and Pang, {K. F.} and Bland, {D. A.} and Mifflin, {R. C.} and {Di Mari}, {J. F.} and Powell, {D. W.}",

year = "2004",

doi = "10.1196/annals.1309.023",

language = "English (US)",

volume = "1029",

pages = "379--381",

journal = "Annals of the New York Academy of Sciences",

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T1 - Intestinal myofibroblasts and immune tolerance

AU - Saada, J. I.

AU - Barrera, C. A.

AU - Reyes, V. E.

AU - Adegboyega, P. A.

AU - Suarez, G.

AU - Tamerisa, R. A.

AU - Pang, K. F.

AU - Bland, D. A.

AU - Mifflin, R. C.

AU - Di Mari, J. F.

AU - Powell, D. W.

PY - 2004

Y1 - 2004

N2 - Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4+ T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.

AB - Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4+ T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.

KW - Antigen-presenting cell

KW - Fibroblastic sheath

KW - HLA-DR

KW - Immune tolerance

KW - Mucosal immunity

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Intestinal myofibroblasts and immune tolerance

Abstract

Keywords

ASJC Scopus subject areas

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