Intestinal myofibroblasts and immune tolerance

J. I. Saada; C. A. Barrera; V. E. Reyes; P. A. Adegboyega; G. Suarez; R. A. Tamerisa; K. F. Pang; D. A. Bland; R. C. Mifflin; J. F. Di Mari; D. W. Powell

doi:10.1196/annals.1309.023

Intestinal myofibroblasts and immune tolerance

J. I. Saada
, C. A. Barrera
, V. E. Reyes
, P. A. Adegboyega
, G. Suarez
, R. A. Tamerisa
, K. F. Pang
, D. A. Bland
, R. C. Mifflin
, J. F. Di Mari
, D. W. Powell

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4⁺ T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.

Original language	English (US)
Pages (from-to)	379-381
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1029
DOIs	https://doi.org/10.1196/annals.1309.023
State	Published - 2004

Keywords

Antigen-presenting cell
Fibroblastic sheath
HLA-DR
Immune tolerance
Mucosal immunity

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1196/annals.1309.023

Cite this

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title = "Intestinal myofibroblasts and immune tolerance",

abstract = "Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4+ T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.",

keywords = "Antigen-presenting cell, Fibroblastic sheath, HLA-DR, Immune tolerance, Mucosal immunity",

author = "Saada, \{J. I.\} and Barrera, \{C. A.\} and Reyes, \{V. E.\} and Adegboyega, \{P. A.\} and G. Suarez and Tamerisa, \{R. A.\} and Pang, \{K. F.\} and Bland, \{D. A.\} and Mifflin, \{R. C.\} and \{Di Mari\}, \{J. F.\} and Powell, \{D. W.\}",

year = "2004",

doi = "10.1196/annals.1309.023",

language = "English (US)",

volume = "1029",

pages = "379--381",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Intestinal myofibroblasts and immune tolerance

AU - Saada, J. I.

AU - Barrera, C. A.

AU - Reyes, V. E.

AU - Adegboyega, P. A.

AU - Suarez, G.

AU - Tamerisa, R. A.

AU - Pang, K. F.

AU - Bland, D. A.

AU - Mifflin, R. C.

AU - Di Mari, J. F.

AU - Powell, D. W.

PY - 2004

Y1 - 2004

N2 - Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4+ T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.

AB - Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4+ T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.

KW - Antigen-presenting cell

KW - Fibroblastic sheath

KW - HLA-DR

KW - Immune tolerance

KW - Mucosal immunity

UR - https://www.scopus.com/pages/publications/20044383918

UR - https://www.scopus.com/pages/publications/20044383918#tab=citedBy

U2 - 10.1196/annals.1309.023

DO - 10.1196/annals.1309.023

M3 - Article

C2 - 15681786

AN - SCOPUS:20044383918

SN - 0077-8923

VL - 1029

SP - 379

EP - 381

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Intestinal myofibroblasts and immune tolerance

Abstract

Keywords

ASJC Scopus subject areas

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