Intestinal myofibroblasts

Targets for stem cell therapy

R. C. Mifflin, Iryna Pinchuk, J. I. Saada, D. W. Powell

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The subepithelial intestinal myofibroblast is an important cell orchestrating many diverse functions in the intestine and is involved in growth and repair, tumorigenesis, inflammation, and fibrosis. The myofibroblast is but one of several α-smooth muscle actin-positive (α-SMA+) mesenchymal cells present within the intestinal lamina propria, including vascular pericytes, bone marrow-derived stem cells (mesenchymal stem cells or hematopoietic stem cells), muscularis mucosae, and the lymphatic pericytes (colon) and organized smooth muscle (small intestine) associated with the lymphatic lacteals. These other mesenchymal cells perform many of the functions previously attributed to subepithelial myofibroblasts. This review discusses the definition of a myofibroblast and reconsiders whether the α-SMA+ subepithelial cells in the intestine are myofibroblasts or other types of mesenchymal cells, i.e., pericytes. Current information about specific, or not so specific, molecular markers of lamina propria mesenchymal cells is reviewed, as well as the origins of intestinal myofibroblasts and pericytes in the intestinal lamina propria and their replenishment after injury. Current concepts and research on stem cell therapy for intestinal inflammation are summarized. Information about the stem cell origin of intestinal stromal cells may inform future stem cell therapies to treat human inflammatory bowel disease (IBD).

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume300
Issue number5
DOIs
StatePublished - May 2011

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Myofibroblasts
Cell- and Tissue-Based Therapy
Pericytes
Stem Cells
Mucous Membrane
Intestines
Smooth Muscle
Inflammation
Stromal Cells
Hematopoietic Stem Cells
Mesenchymal Stromal Cells
Inflammatory Bowel Diseases
Small Intestine
Blood Vessels
Actins
Colon
Carcinogenesis
Milk
Fibrosis
Bone Marrow

Keywords

  • α-smooth muscle actin
  • Bone marrow stem cells
  • Bone marrow transplantation
  • Crohn's disease
  • Epimorphin
  • Fibroblast activation protein
  • Fibroblastspecific protein 1
  • Hematopoietic stem cells
  • Inflammatory bowel disease
  • Injury and repair
  • Lymphatic lacteal
  • Mesenchymal cells
  • Mesenchymal stem cells
  • Muscularis mucosae
  • NG2
  • Patched
  • Pericytes
  • Periostin
  • Stromal cells
  • Thy-1
  • Thymic antigens

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology (medical)
  • Physiology
  • Hepatology

Cite this

Intestinal myofibroblasts : Targets for stem cell therapy. / Mifflin, R. C.; Pinchuk, Iryna; Saada, J. I.; Powell, D. W.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 300, No. 5, 05.2011.

Research output: Contribution to journalArticle

Mifflin, R. C. ; Pinchuk, Iryna ; Saada, J. I. ; Powell, D. W. / Intestinal myofibroblasts : Targets for stem cell therapy. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 2011 ; Vol. 300, No. 5.
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