Intraamniotic inflammation in women with preterm prelabor rupture of membranes

Ivana Musilova, Radka Kutová, Lenka Pliskova, Martin Stepan, Ramkumar Menon, Bo Jacobsson, Marian Kacerovsky

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: To characterize subgroups of preterm prelabor rupture of membranes (PPROM) and shortterm neonatal outcomes based on the presence and absence of intraamniotic inflammation (IAI) and/or microbial invasion of the amniotic cavity (MIAC). Methods: One hundred and sixty-six Caucasian women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis (n=166) and were assayed for interleukin-6 levels by a lateral flow immunoassay. The presence of Ureaplasma species, Mycoplasma hominis, Chlamydia trachomatis, and 16S rRNA was evaluated in the amniotic fluid. IAI was defined as amniotic fluid IL-6 values, measured by a point of care test, higher than 745 pg/mL. Results: Microbial-associated IAI (IAI with MIAC) and sterile intraamniotic inflammation (IAI alone) were found in 21%and 4%, respectively, of women with PPROM. Women with microbialassociated IAI had higher microbial loads of Ureaplasma species in the amniotic fluid than women with MIAC alone. No differences in the short-term neonatal morbidity with respect to the presence of microbial-associated IAI, sterile IAI and MIAC alone were found after adjusting for the gestational age at delivery in women with PPROM. Conclusions: Microbial-associated but not sterile intraamniotic inflammation is common in Caucasian women with PPROM. The gestational age at delivery but not the presence of inflammation affects the short-term neonatal morbidity of newborns from PPROM pregnancies.

Original languageEnglish (US)
Article numbere0133929
JournalPLoS One
Volume10
Issue number7
DOIs
StatePublished - Jul 24 2015
Externally publishedYes

Fingerprint

Rupture
inflammation
Inflammation
Membranes
Fluids
amniotic fluid
Amniotic Fluid
Interleukin-6
Ureaplasma
gestational age
interleukin-6
Gestational Age
morbidity
Mycoplasma hominis
Point-of-Care Systems
pregnancy
Chlamydia trachomatis
Morbidity
Pregnancy
microbial load

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Musilova, I., Kutová, R., Pliskova, L., Stepan, M., Menon, R., Jacobsson, B., & Kacerovsky, M. (2015). Intraamniotic inflammation in women with preterm prelabor rupture of membranes. PLoS One, 10(7), [e0133929]. https://doi.org/10.1371/journal.pone.0133929

Intraamniotic inflammation in women with preterm prelabor rupture of membranes. / Musilova, Ivana; Kutová, Radka; Pliskova, Lenka; Stepan, Martin; Menon, Ramkumar; Jacobsson, Bo; Kacerovsky, Marian.

In: PLoS One, Vol. 10, No. 7, e0133929, 24.07.2015.

Research output: Contribution to journalArticle

Musilova, I, Kutová, R, Pliskova, L, Stepan, M, Menon, R, Jacobsson, B & Kacerovsky, M 2015, 'Intraamniotic inflammation in women with preterm prelabor rupture of membranes', PLoS One, vol. 10, no. 7, e0133929. https://doi.org/10.1371/journal.pone.0133929
Musilova I, Kutová R, Pliskova L, Stepan M, Menon R, Jacobsson B et al. Intraamniotic inflammation in women with preterm prelabor rupture of membranes. PLoS One. 2015 Jul 24;10(7). e0133929. https://doi.org/10.1371/journal.pone.0133929
Musilova, Ivana ; Kutová, Radka ; Pliskova, Lenka ; Stepan, Martin ; Menon, Ramkumar ; Jacobsson, Bo ; Kacerovsky, Marian. / Intraamniotic inflammation in women with preterm prelabor rupture of membranes. In: PLoS One. 2015 ; Vol. 10, No. 7.
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