@article{c2d9b9bc45054b3b8808d10e09f08fb5,
title = "Intraarterial delivery of virotherapy for glioblastoma",
abstract = "Oncolytic viruses (OVs) have been used in the treatment of cancer, in a focused manner, since the 1990s. These OVs have become popular in the treatment of several cancers but are only now gaining interest in the treatment of glioblastoma (GBM) in recent clinical trials. In this review, the authors discuss the unique applications of intraarterial (IA) delivery of OVs, starting with concepts of OV, how they apply to IA delivery, and concluding with discussion of the current ongoing trials. Several OVs have been used in the treatment of GBM, including specifically several modified adenoviruses. IA delivery of OVs has been performed in the hepatic circulation and is now being studied in the cerebral circulation to help enhance delivery and specificity. There are some interesting synergies with immunotherapy and IA delivery of OVs. Some of the shortcomings are discussed, specifically the systemic response to OVs and feasibility of treatment. Future studies can be performed in the preclinical setting to identify the ideal candidates for translation into clinical trials, as well as the nuances of this novel delivery method.",
keywords = "endovascular, glioblastoma, intraarterial, oncolytic, stem cell, virotherapy",
author = "Srinivasan, {Visish M.} and Lang, {Frederick F.} and Peter Kan",
note = "Funding Information: This study was supported by the National Cancer Institute Funding Information: This study was supported by the National Cancer Institute (grant nos. 1R01CA214749, 1R01CA247970, and 2P50CA127001), The University of Texas MD Anderson Moon Shots Program, the Broach Foundation for Brain Cancer Research, the Elias Family Fund, the Priscila and Jason Hiley Fund, the Baumann Family/Curefest Fund, the Jim and Pam Harris Fund, the Gene Pennebaker Brain Cancer Fund, the Schneider Memorial Fund, the Sweet Family Cancer Research Fund, the Dr. Marnie Rose Foundation, the Gold Family Memorial Fund, and the Sorenson Foundation (all to Dr. Lang). Funding Information: (grant nos. 1R01CA214749, 1R01CA247970, and 2P50CA127001), The University of Texas MD Anderson Moon Shots Program, the Broach Foundation for Brain Cancer Research, the Elias Family Fund, the Priscila and Jason Hiley Fund, the Baumann Family/ Curefest Fund, the Jim and Pam Harris Fund, the Gene Pennebak-er Brain Cancer Fund, the Schneider Memorial Fund, the Sweet Family Cancer Research Fund, the Dr. Marnie Rose Foundation, the Gold Family Memorial Fund, and the Sorenson Foundation (all to Dr. Lang). Publisher Copyright: {\textcopyright} AANS 2021. except where prohibited by US copyright law.",
year = "2021",
month = feb,
doi = "10.3171/2020.11.FOCUS20845",
language = "English (US)",
volume = "50",
pages = "1--9",
journal = "Neurosurgical Focus",
issn = "1092-0684",
publisher = "American Association of Neurological Surgeons",
number = "2",
}