Intracellular Casp8p41 content is inversely associated with CD4 T cell count

Nathan W. Cummins; Wei Jiang; John McGinty; Gary D. Bren; Ronald J. Bosch; Alan Landay; Steven G. Deeks; Jeffrey N. Martin; Daniel Douek; Michael M. Lederman; Jason Brenchley; Andrew D. Badley

doi:10.1086/653705

Intracellular Casp8p41 content is inversely associated with CD4 T cell count

Nathan W. Cummins, Wei Jiang, John McGinty, Gary D. Bren, Ronald J. Bosch, Alan Landay, Steven G. Deeks, Jeffrey N. Martin, Daniel Douek, Michael M. Lederman, Jason Brenchley, Andrew D. Badley

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.

Original language	English (US)
Pages (from-to)	386-391
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	202
Issue number	3
DOIs	https://doi.org/10.1086/653705
State	Published - Aug 1 2010
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1086/653705

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title = "Intracellular Casp8p41 content is inversely associated with CD4 T cell count",

abstract = "Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.",

author = "Cummins, {Nathan W.} and Wei Jiang and John McGinty and Bren, {Gary D.} and Bosch, {Ronald J.} and Alan Landay and Deeks, {Steven G.} and Martin, {Jeffrey N.} and Daniel Douek and Lederman, {Michael M.} and Jason Brenchley and Badley, {Andrew D.}",

year = "2010",

month = aug,

day = "1",

doi = "10.1086/653705",

language = "English (US)",

volume = "202",

pages = "386--391",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Intracellular Casp8p41 content is inversely associated with CD4 T cell count

AU - Cummins, Nathan W.

AU - Jiang, Wei

AU - McGinty, John

AU - Bren, Gary D.

AU - Bosch, Ronald J.

AU - Landay, Alan

AU - Deeks, Steven G.

AU - Martin, Jeffrey N.

AU - Douek, Daniel

AU - Lederman, Michael M.

AU - Brenchley, Jason

AU - Badley, Andrew D.

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.

AB - Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.

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Intracellular Casp8p41 content is inversely associated with CD4 T cell count

Abstract

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