Intracellular diglycerides in relation to glycaemic control in the myocardium: A pilot study in humans

C. A. Anastasiou, A. Stamatelopoulos, P. Dedeilias, C. Charitos, L. S. Sidossis, S. A. Kavouras

Research output: Contribution to journalArticle

Abstract

Aim: Intramyocellular diglycerides have been implicated in the development of insulin resistance in skeletal muscle. In the myocardium, excess lipid storage may also contribute to the appearance of diabetic cardiomyopathy, while diglycerides may have certain cardio-protective functions. However, little is known on intracellular diglyceride accumulation in the human heart. We aimed to determine diglyceride accumulation in the human myocardium in relation to diabetes status. Methods: Six diabetic and six non-diabetic aged human subjects undergoing by-pass surgery participated in the study. Subjects were matched for age and body mass index. Intracellular diglyceride levels were measured in heart biopsy samples. Additional samples were taken from pectoralis major muscle that served as control. Whole body glycaemic control was assessed as the percent glycated haemoglobin. Results: Intracellular diglycerides were significantly higher in the myocardium compared to pectoralis major (. P

Original languageEnglish (US)
Pages (from-to)422-424
Number of pages3
JournalDiabetes and Metabolism
Volume41
Issue number5
DOIs
StatePublished - Nov 1 2015

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Keywords

  • Diabetes
  • Diglycerides
  • Heart
  • Insulin resistance
  • Myocardium

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Anastasiou, C. A., Stamatelopoulos, A., Dedeilias, P., Charitos, C., Sidossis, L. S., & Kavouras, S. A. (2015). Intracellular diglycerides in relation to glycaemic control in the myocardium: A pilot study in humans. Diabetes and Metabolism, 41(5), 422-424. https://doi.org/10.1016/j.diabet.2015.04.002