Intracellular diglycerides in relation to glycaemic control in the myocardium

A pilot study in humans

C. A. Anastasiou, A. Stamatelopoulos, P. Dedeilias, C. Charitos, L. S. Sidossis, S. A. Kavouras

Research output: Contribution to journalArticle

Abstract

Aim: Intramyocellular diglycerides have been implicated in the development of insulin resistance in skeletal muscle. In the myocardium, excess lipid storage may also contribute to the appearance of diabetic cardiomyopathy, while diglycerides may have certain cardio-protective functions. However, little is known on intracellular diglyceride accumulation in the human heart. We aimed to determine diglyceride accumulation in the human myocardium in relation to diabetes status. Methods: Six diabetic and six non-diabetic aged human subjects undergoing by-pass surgery participated in the study. Subjects were matched for age and body mass index. Intracellular diglyceride levels were measured in heart biopsy samples. Additional samples were taken from pectoralis major muscle that served as control. Whole body glycaemic control was assessed as the percent glycated haemoglobin. Results: Intracellular diglycerides were significantly higher in the myocardium compared to pectoralis major (. P

Original languageEnglish (US)
Pages (from-to)422-424
Number of pages3
JournalDiabetes and Metabolism
Volume41
Issue number5
DOIs
StatePublished - Nov 1 2015

Fingerprint

Diglycerides
Myocardium
Diabetic Cardiomyopathies
Pectoralis Muscles
Glycosylated Hemoglobin A
Insulin Resistance
Skeletal Muscle
Body Mass Index
Lipids
Biopsy

Keywords

  • Diabetes
  • Diglycerides
  • Heart
  • Insulin resistance
  • Myocardium

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Anastasiou, C. A., Stamatelopoulos, A., Dedeilias, P., Charitos, C., Sidossis, L. S., & Kavouras, S. A. (2015). Intracellular diglycerides in relation to glycaemic control in the myocardium: A pilot study in humans. Diabetes and Metabolism, 41(5), 422-424. https://doi.org/10.1016/j.diabet.2015.04.002

Intracellular diglycerides in relation to glycaemic control in the myocardium : A pilot study in humans. / Anastasiou, C. A.; Stamatelopoulos, A.; Dedeilias, P.; Charitos, C.; Sidossis, L. S.; Kavouras, S. A.

In: Diabetes and Metabolism, Vol. 41, No. 5, 01.11.2015, p. 422-424.

Research output: Contribution to journalArticle

Anastasiou, CA, Stamatelopoulos, A, Dedeilias, P, Charitos, C, Sidossis, LS & Kavouras, SA 2015, 'Intracellular diglycerides in relation to glycaemic control in the myocardium: A pilot study in humans', Diabetes and Metabolism, vol. 41, no. 5, pp. 422-424. https://doi.org/10.1016/j.diabet.2015.04.002
Anastasiou CA, Stamatelopoulos A, Dedeilias P, Charitos C, Sidossis LS, Kavouras SA. Intracellular diglycerides in relation to glycaemic control in the myocardium: A pilot study in humans. Diabetes and Metabolism. 2015 Nov 1;41(5):422-424. https://doi.org/10.1016/j.diabet.2015.04.002
Anastasiou, C. A. ; Stamatelopoulos, A. ; Dedeilias, P. ; Charitos, C. ; Sidossis, L. S. ; Kavouras, S. A. / Intracellular diglycerides in relation to glycaemic control in the myocardium : A pilot study in humans. In: Diabetes and Metabolism. 2015 ; Vol. 41, No. 5. pp. 422-424.
@article{56663ceaf71f46608f46db157ae01bd8,
title = "Intracellular diglycerides in relation to glycaemic control in the myocardium: A pilot study in humans",
abstract = "Aim: Intramyocellular diglycerides have been implicated in the development of insulin resistance in skeletal muscle. In the myocardium, excess lipid storage may also contribute to the appearance of diabetic cardiomyopathy, while diglycerides may have certain cardio-protective functions. However, little is known on intracellular diglyceride accumulation in the human heart. We aimed to determine diglyceride accumulation in the human myocardium in relation to diabetes status. Methods: Six diabetic and six non-diabetic aged human subjects undergoing by-pass surgery participated in the study. Subjects were matched for age and body mass index. Intracellular diglyceride levels were measured in heart biopsy samples. Additional samples were taken from pectoralis major muscle that served as control. Whole body glycaemic control was assessed as the percent glycated haemoglobin. Results: Intracellular diglycerides were significantly higher in the myocardium compared to pectoralis major (. P",
keywords = "Diabetes, Diglycerides, Heart, Insulin resistance, Myocardium",
author = "Anastasiou, {C. A.} and A. Stamatelopoulos and P. Dedeilias and C. Charitos and Sidossis, {L. S.} and Kavouras, {S. A.}",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.diabet.2015.04.002",
language = "English (US)",
volume = "41",
pages = "422--424",
journal = "Diabetes and Metabolism",
issn = "1262-3636",
publisher = "Elsevier Masson",
number = "5",

}

TY - JOUR

T1 - Intracellular diglycerides in relation to glycaemic control in the myocardium

T2 - A pilot study in humans

AU - Anastasiou, C. A.

AU - Stamatelopoulos, A.

AU - Dedeilias, P.

AU - Charitos, C.

AU - Sidossis, L. S.

AU - Kavouras, S. A.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Aim: Intramyocellular diglycerides have been implicated in the development of insulin resistance in skeletal muscle. In the myocardium, excess lipid storage may also contribute to the appearance of diabetic cardiomyopathy, while diglycerides may have certain cardio-protective functions. However, little is known on intracellular diglyceride accumulation in the human heart. We aimed to determine diglyceride accumulation in the human myocardium in relation to diabetes status. Methods: Six diabetic and six non-diabetic aged human subjects undergoing by-pass surgery participated in the study. Subjects were matched for age and body mass index. Intracellular diglyceride levels were measured in heart biopsy samples. Additional samples were taken from pectoralis major muscle that served as control. Whole body glycaemic control was assessed as the percent glycated haemoglobin. Results: Intracellular diglycerides were significantly higher in the myocardium compared to pectoralis major (. P

AB - Aim: Intramyocellular diglycerides have been implicated in the development of insulin resistance in skeletal muscle. In the myocardium, excess lipid storage may also contribute to the appearance of diabetic cardiomyopathy, while diglycerides may have certain cardio-protective functions. However, little is known on intracellular diglyceride accumulation in the human heart. We aimed to determine diglyceride accumulation in the human myocardium in relation to diabetes status. Methods: Six diabetic and six non-diabetic aged human subjects undergoing by-pass surgery participated in the study. Subjects were matched for age and body mass index. Intracellular diglyceride levels were measured in heart biopsy samples. Additional samples were taken from pectoralis major muscle that served as control. Whole body glycaemic control was assessed as the percent glycated haemoglobin. Results: Intracellular diglycerides were significantly higher in the myocardium compared to pectoralis major (. P

KW - Diabetes

KW - Diglycerides

KW - Heart

KW - Insulin resistance

KW - Myocardium

UR - http://www.scopus.com/inward/record.url?scp=84947037682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947037682&partnerID=8YFLogxK

U2 - 10.1016/j.diabet.2015.04.002

DO - 10.1016/j.diabet.2015.04.002

M3 - Article

VL - 41

SP - 422

EP - 424

JO - Diabetes and Metabolism

JF - Diabetes and Metabolism

SN - 1262-3636

IS - 5

ER -