Abstract
Intracerebroventricular (i.c.v.) administration of salmon calcitonin (500 ng) augmented glucose-stimulated release of insulin in rats. Vagotomy increased this enhancement effect of i.c.v. calcitonin significantly, whereas peripheral atropine treatment did not change it. Adrenal catecholamines did not participate in the centrally mediated insulinotropic effect of calcitonin since acute adrenalectomy did not modify the enhancement effect of i.c.v. calcitonin. Destruction of the sympathetic ganglia by neonatal treatment with 6-hydroxydopamine abolished the enhancement effect of i.c.v. calcitonin, which suggests that the sympathetic nervous system participates in the central action of calcitonin to enhance glucose-stimulated release of insulin.
Original language | English (US) |
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Pages (from-to) | 259-268 |
Number of pages | 10 |
Journal | Regulatory Peptides |
Volume | 24 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1989 |
Externally published | Yes |
Keywords
- 6-Hydroxydopamine
- Adrenalectomy
- Brain
- Central nervous system
- Intracerebroventricular
- Rat
ASJC Scopus subject areas
- Endocrinology
- Cellular and Molecular Neuroscience
- Biochemistry
- Physiology
- Clinical Biochemistry