Intracerebroventricular administration of calcitonin enhances glucose-stimulated release of insulin

George H. Greeley, Cary W. Cooper, Yow Jiun Jeng, J. Charles Eldridge, James C. Thompson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Intracerebroventricular (i.c.v.) administration of salmon calcitonin (500 ng) augmented glucose-stimulated release of insulin in rats. Vagotomy increased this enhancement effect of i.c.v. calcitonin significantly, whereas peripheral atropine treatment did not change it. Adrenal catecholamines did not participate in the centrally mediated insulinotropic effect of calcitonin since acute adrenalectomy did not modify the enhancement effect of i.c.v. calcitonin. Destruction of the sympathetic ganglia by neonatal treatment with 6-hydroxydopamine abolished the enhancement effect of i.c.v. calcitonin, which suggests that the sympathetic nervous system participates in the central action of calcitonin to enhance glucose-stimulated release of insulin.

Original languageEnglish (US)
Pages (from-to)259-268
Number of pages10
JournalRegulatory Peptides
Volume24
Issue number3
DOIs
StatePublished - Mar 1989
Externally publishedYes

Keywords

  • 6-Hydroxydopamine
  • Adrenalectomy
  • Brain
  • Central nervous system
  • Intracerebroventricular
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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