Intracerebroventricular administration of calcitonin enhances glucose-stimulated release of insulin

George H. Greeley, Cary W. Cooper, Yow Jiun Jeng, J. Charles Eldridge, James C. Thompson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Intracerebroventricular (i.c.v.) administration of salmon calcitonin (500 ng) augmented glucose-stimulated release of insulin in rats. Vagotomy increased this enhancement effect of i.c.v. calcitonin significantly, whereas peripheral atropine treatment did not change it. Adrenal catecholamines did not participate in the centrally mediated insulinotropic effect of calcitonin since acute adrenalectomy did not modify the enhancement effect of i.c.v. calcitonin. Destruction of the sympathetic ganglia by neonatal treatment with 6-hydroxydopamine abolished the enhancement effect of i.c.v. calcitonin, which suggests that the sympathetic nervous system participates in the central action of calcitonin to enhance glucose-stimulated release of insulin.

Original languageEnglish (US)
Pages (from-to)259-268
Number of pages10
JournalRegulatory Peptides
Volume24
Issue number3
DOIs
StatePublished - 1989

Fingerprint

Calcitonin
Insulin
Glucose
salmon calcitonin
Sympathetic Ganglia
Vagotomy
Oxidopamine
Adrenalectomy
Sympathetic Nervous System
Neurology
Atropine
Catecholamines
Rats

Keywords

  • 6-Hydroxydopamine
  • Adrenalectomy
  • Brain
  • Central nervous system
  • Intracerebroventricular
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Intracerebroventricular administration of calcitonin enhances glucose-stimulated release of insulin. / Greeley, George H.; Cooper, Cary W.; Jeng, Yow Jiun; Eldridge, J. Charles; Thompson, James C.

In: Regulatory Peptides, Vol. 24, No. 3, 1989, p. 259-268.

Research output: Contribution to journalArticle

Greeley, George H. ; Cooper, Cary W. ; Jeng, Yow Jiun ; Eldridge, J. Charles ; Thompson, James C. / Intracerebroventricular administration of calcitonin enhances glucose-stimulated release of insulin. In: Regulatory Peptides. 1989 ; Vol. 24, No. 3. pp. 259-268.
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