Intracerebroventricular administration of cholecystokinin-8 elevates plasma pancreatic polypeptide levels in awake dogs

Q. H. Lu, G. H. Greeley, X. G. Zhu, J. C. Thompson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of intracerebroventricular (ICV) administration of cholecystokinin-8 (CCK-8) (0.5, 1.0, 2.0, 4.0 μg) on plasma levels of pancreatic polypeptide (PP) was studied in conscious dogs. ICV administration of CCK-8 (1.0, 2.0, 4.0 μg) produced a rapid and transient elevation in plasma concentrations of PP. Peripheral muscarinic receptor blockade with atropine or truncal vagotomy abolished PP secretion induced by ICV CCK-8. Pretreatment with ICV atropine also prevented the elevation in plasma PP induced by CCK-8. Plasma levels of CCK-33/39, CCK-8, and gastrin were not affected by ICV CCK-8. Our results indicate that central administration of CCK-8 selectively elevated plasma PP concentration. Since the effect of CCK-8 on plasma PP was abolished by central and peripheral atropine pretreatment, as well as by vagotomy, central and peripheral vagal cholinergic mechanisms appear to participate in release of PP that is induced by CCK-8 given by ICV injection.

Original languageEnglish (US)
Pages (from-to)2415-2417
Number of pages3
JournalEndocrinology
Volume114
Issue number6
StatePublished - 1984

Fingerprint

Pancreatic Polypeptide
Dogs
Atropine
Truncal Vagotomy
cholecystokinin 8
Vagotomy
Cholecystokinin
Gastrins
Muscarinic Receptors
Cholinergic Agents
Injections

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Lu, Q. H., Greeley, G. H., Zhu, X. G., & Thompson, J. C. (1984). Intracerebroventricular administration of cholecystokinin-8 elevates plasma pancreatic polypeptide levels in awake dogs. Endocrinology, 114(6), 2415-2417.

Intracerebroventricular administration of cholecystokinin-8 elevates plasma pancreatic polypeptide levels in awake dogs. / Lu, Q. H.; Greeley, G. H.; Zhu, X. G.; Thompson, J. C.

In: Endocrinology, Vol. 114, No. 6, 1984, p. 2415-2417.

Research output: Contribution to journalArticle

Lu, Q. H. ; Greeley, G. H. ; Zhu, X. G. ; Thompson, J. C. / Intracerebroventricular administration of cholecystokinin-8 elevates plasma pancreatic polypeptide levels in awake dogs. In: Endocrinology. 1984 ; Vol. 114, No. 6. pp. 2415-2417.
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