Intracolonic infusion of bile salt stimulates release of peptide YY and inhibits cholecystokinin-stimulated pancreatic exocrine secretion in conscious dogs

M. Izukura, T. Hashimoto, Guillermo Gomez, T. Uchida, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The purpose of this study was to examine the effect of transanal (intracolonic) infusion of bile acid on release of peptide YY (PYY) and cholecystokinin (CCK)-stimulated pancreatic exocrine secretion in seven conscious dogs. CCK-8 (50 ng/kg/h) was given intravenously for 120 min and either taurocholic acid (TA, 1 or 2 mmol/h) or saline was infused transanally (150 ml/h) during the 0-60-min period of CCK infusion. Transanal infusion of TA (1 or 2 mmol/h) significantly inhibited output of CCK-8-stimulated pancreatic protein, compared to transanal infusion of saline during the first 60 min. On the average, the magnitude of inhibition was ~45%. Plasma concentrations of PYY increased significantly in response to intracolonic infusion of TA or saline. Transanal infusion of TA (1 or 2 mmol/h) significantly increased plasma levels of PYY when compared with transanal infusion of saline during the first 60 min. The magnitude of the increase of plasma PYY levels was ~50 pg/ml (p < 0.05). Plasma levels of pancreatic polypeptide were not altered significantly by transanal infusion of TA. Our results suggest that release of endogenous PYY by TA in the colon plays a role in the inhibition of CCK-stimulated pancreatic exocrine secretion. Bile salts in the hindgut may participate in the physiologic regulation of pancreatic exocrine secretion by stimulation of release of ileal-colonic PYY.

Original languageEnglish (US)
Pages (from-to)427-432
Number of pages6
JournalPancreas
Volume6
Issue number4
StatePublished - 1991

Fingerprint

Peptide YY
Cholecystokinin
Bile Acids and Salts
Dogs
Pancreatic Polypeptide
Taurocholic Acid
Colon

Keywords

  • Colon
  • Feedback
  • Pancreas
  • Pancreatic enzymes

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology

Cite this

Izukura, M., Hashimoto, T., Gomez, G., Uchida, T., Greeley, G. H., & Thompson, J. C. (1991). Intracolonic infusion of bile salt stimulates release of peptide YY and inhibits cholecystokinin-stimulated pancreatic exocrine secretion in conscious dogs. Pancreas, 6(4), 427-432.

Intracolonic infusion of bile salt stimulates release of peptide YY and inhibits cholecystokinin-stimulated pancreatic exocrine secretion in conscious dogs. / Izukura, M.; Hashimoto, T.; Gomez, Guillermo; Uchida, T.; Greeley, G. H.; Thompson, J. C.

In: Pancreas, Vol. 6, No. 4, 1991, p. 427-432.

Research output: Contribution to journalArticle

Izukura, M, Hashimoto, T, Gomez, G, Uchida, T, Greeley, GH & Thompson, JC 1991, 'Intracolonic infusion of bile salt stimulates release of peptide YY and inhibits cholecystokinin-stimulated pancreatic exocrine secretion in conscious dogs', Pancreas, vol. 6, no. 4, pp. 427-432.
Izukura, M. ; Hashimoto, T. ; Gomez, Guillermo ; Uchida, T. ; Greeley, G. H. ; Thompson, J. C. / Intracolonic infusion of bile salt stimulates release of peptide YY and inhibits cholecystokinin-stimulated pancreatic exocrine secretion in conscious dogs. In: Pancreas. 1991 ; Vol. 6, No. 4. pp. 427-432.
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