Intragenic suppression of an active site mutation in the human apurinic/apyrimidinic endonuclease

Keyphrases

• Mg2+ 100%
• Suppressor mutant 100%
• Active Site mutant 100%
• Human Apurinic/apyrimidinic Endonuclease 100%
• Endonuclease 50%
• Metal Binding Site 50%
• Mutant Protein 50%
• DNA Binding 25%
• Complementary DNA (cDNA) 25%
• Escherichia Coli 25%
• AP Endonuclease 25%
• X-ray Crystal Structure 25%
• Site-directed mutation 25%
• Random mutagenesis 25%
• Local Perturbation 25%
• Acid Residue 25%
• Endonuclease Activity 25%
• Protein Conformation 25%
• In the Wild 25%
• Single-point mutation 25%
• Glutamic Acid 25%
• Phosphotriesterase 25%
• Conserved Sequence 25%
• Global Change 25%
• Double mutation 25%
• Tryptophan Residues 25%
• Second-site mutation 25%
• Consensus Motifs 25%
• Phenotypic Screening 25%
• Structural Environment 25%
• Mutation Study 25%
• Catalytic Steps 25%
• Intragenic Suppressor 25%
• Flexible Conformation 25%

Biochemistry, Genetics and Molecular Biology

• Wild Type 100%
• Active Site 100%
• Endonuclease 100%
• Enzyme 50%
• Binding Site 50%
• Mutant Protein 50%
• Metal Binding 50%
• Conformation 50%
• DNA Binding 25%
• X Ray 25%
• Mutagenesis 25%
• Escherichia coli 25%
• AP Endonuclease 25%
• Protein Conformation 25%
• Conserved Sequence 25%
• Sequence Motif 25%
• Crystal Structure 25%
• Phosphatase 25%
• Tryptophan 25%
• Glutamic Acid 25%

Immunology and Microbiology

• Wild Type 100%
• Binding Site 50%
• Conformation 50%
• Metal Binding 50%
• DNA Binding 25%
• X Ray 25%
• Mutagenesis 25%
• Escherichia coli 25%
• Protein Conformation 25%
• Conserved Sequence 25%