Intragraft Gene Expression Profile During Acute Cellular Rejection in Clinical Small Bowel Transplantation: A Case Report

S. P. Bradley, M. Pahari, G. Elias, M. E. Uknis, M. V. Misra, C. Rastellini, L. Cicalese

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Acute cellular rejection (ACR) is a common complication of small bowel transplantation (SBTx) and the major cause of graft loss. However, little is known regarding the genetic graft response to ACR in clinical transplants. In this study, we have determined a genetic expression profile of intestinal graft response to ACR after living related (LR) SBTx. Results: By identifying the expression profiles of reported markers of rejection we were able to identify 57 genes that had significantly increased (more than twofold) expression in response to ACR. Known markers of rejection identified: MMP-9, MMP-2, VIP, IFNγ, IL-2R, MADCAM-1, HSP-60, and HSP-70 all had greater than twofold increased expression after ACR diagnosed (week 3 to week 6). The newly identified genes were: IFI27, EPST11, APAF1, LAP3, STK6, and MDK. Conclusion: Newly identified up-regulated genes in response to ACR in small bowel graft are involved in the immune response, cell adhesion, neurogenesis, cell division and proliferation, DNA replication/repair, protein ubiqutin/proteolysis, and apoptosis. TNFα up-regulated early at week 2 biopsy may be an early genetic marker of ACR in SBTx.

Original languageEnglish (US)
Pages (from-to)1740-1741
Number of pages2
JournalTransplantation Proceedings
Volume38
Issue number6
DOIs
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Fingerprint Dive into the research topics of 'Intragraft Gene Expression Profile During Acute Cellular Rejection in Clinical Small Bowel Transplantation: A Case Report'. Together they form a unique fingerprint.

  • Cite this