Intrahepatic Cholestasis of Pregnancy: Toward Improving Perinatal Outcome

Antonio F. Saad; Luis D. Pacheco; Lucy Chappell; George R. Saade

doi:10.1007/s43032-021-00740-x

Intrahepatic Cholestasis of Pregnancy: Toward Improving Perinatal Outcome

Antonio F. Saad, Luis D. Pacheco, Lucy Chappell, George R. Saade

Obstetrics & Gynecology

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is associated with poor perinatal outcomes in some women such as preterm delivery and fetal demise. Ursodeoxycholic acid (UDCA) is the main therapeutic agent for ICP, but recent evidence failed to show an impact on most perinatal outcomes. Our objective is to summarize the latest evidence in the management of ICP, with a focus on perinatal outcome. We propose a practical approach that combines pharmacotherapy with biochemical and fetal testing, as well as delivery planning.

Original language	English (US)
Pages (from-to)	3100-3105
Number of pages	6
Journal	Reproductive Sciences
Volume	29
Issue number	11
DOIs	https://doi.org/10.1007/s43032-021-00740-x
State	Published - Nov 2022

Keywords

Bile acid
Cholestasis
Hepatic disease
Pregnancy

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1007/s43032-021-00740-x

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title = "Intrahepatic Cholestasis of Pregnancy: Toward Improving Perinatal Outcome",

abstract = "Intrahepatic cholestasis of pregnancy (ICP) is associated with poor perinatal outcomes in some women such as preterm delivery and fetal demise. Ursodeoxycholic acid (UDCA) is the main therapeutic agent for ICP, but recent evidence failed to show an impact on most perinatal outcomes. Our objective is to summarize the latest evidence in the management of ICP, with a focus on perinatal outcome. We propose a practical approach that combines pharmacotherapy with biochemical and fetal testing, as well as delivery planning.",

keywords = "Bile acid, Cholestasis, Hepatic disease, Pregnancy",

author = "Saad, {Antonio F.} and Pacheco, {Luis D.} and Lucy Chappell and Saade, {George R.}",

note = "Publisher Copyright: {\textcopyright} 2021, Society for Reproductive Investigation.",

year = "2022",

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doi = "10.1007/s43032-021-00740-x",

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T1 - Intrahepatic Cholestasis of Pregnancy

T2 - Toward Improving Perinatal Outcome

AU - Saad, Antonio F.

AU - Pacheco, Luis D.

AU - Chappell, Lucy

AU - Saade, George R.

PY - 2022/11

Y1 - 2022/11

N2 - Intrahepatic cholestasis of pregnancy (ICP) is associated with poor perinatal outcomes in some women such as preterm delivery and fetal demise. Ursodeoxycholic acid (UDCA) is the main therapeutic agent for ICP, but recent evidence failed to show an impact on most perinatal outcomes. Our objective is to summarize the latest evidence in the management of ICP, with a focus on perinatal outcome. We propose a practical approach that combines pharmacotherapy with biochemical and fetal testing, as well as delivery planning.

AB - Intrahepatic cholestasis of pregnancy (ICP) is associated with poor perinatal outcomes in some women such as preterm delivery and fetal demise. Ursodeoxycholic acid (UDCA) is the main therapeutic agent for ICP, but recent evidence failed to show an impact on most perinatal outcomes. Our objective is to summarize the latest evidence in the management of ICP, with a focus on perinatal outcome. We propose a practical approach that combines pharmacotherapy with biochemical and fetal testing, as well as delivery planning.

KW - Bile acid

KW - Cholestasis

KW - Hepatic disease

KW - Pregnancy

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DO - 10.1007/s43032-021-00740-x

M3 - Review article

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JO - Reproductive Sciences

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IS - 11

ER -

Intrahepatic Cholestasis of Pregnancy: Toward Improving Perinatal Outcome

Abstract

Keywords

ASJC Scopus subject areas

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