Intrahepatic Cholestasis of Pregnancy: Toward Improving Perinatal Outcome

Antonio F. Saad, Luis D. Pacheco, Lucy Chappell, George R. Saade

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Intrahepatic cholestasis of pregnancy (ICP) is associated with poor perinatal outcomes in some women such as preterm delivery and fetal demise. Ursodeoxycholic acid (UDCA) is the main therapeutic agent for ICP, but recent evidence failed to show an impact on most perinatal outcomes. Our objective is to summarize the latest evidence in the management of ICP, with a focus on perinatal outcome. We propose a practical approach that combines pharmacotherapy with biochemical and fetal testing, as well as delivery planning.

Original languageEnglish (US)
Pages (from-to)3100-3105
Number of pages6
JournalReproductive Sciences
Issue number11
StatePublished - Nov 2022


  • Bile acid
  • Cholestasis
  • Hepatic disease
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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