Intranodal palisaded myofibroblastoma

Thong Nguyen, Mahmoud A. Eltorky

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Intranodal palisaded myofibroblastoma (IPM) usually presents as a painless, slow-growing inguinal mass. Our review of 42 cases from 13 publications indicates that two thirds of IPMs occur between the ages of 45 and 55 years, the male-female ratio is 2:1, and there is a lack of ethnic predilection. Grossly, the IPM cut surface shows areas of hemorrhage. Five microscopic features are seen: (a) compressed remnants of lymphoid tissue at the periphery; (b) spindle cells with nuclear palisading; (c) intraparenchymal hemorrhage and erythrocyte extravasation; (d) so-called amianthoid fibers; and (e) intracellular and extracellular fuchsinophilic bodies that stain positive for smooth muscle actin. Immunohistochemically, IPM is positive for smooth muscle actin and cyclin D1 and negative for S100, glial fibrillary acidic protein, CD34, and desmin, and it shows a low proliferative index of Ki-67. Electron microscopy demonstrates features of myofibroblasts and smooth muscle cells. Excellent prognosis is seen after surgical treatment, with an approximately 6% recurrence rate and no malignant transformation.

Original languageEnglish
Pages (from-to)306-310
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume131
Issue number2
StatePublished - Feb 2007

Fingerprint

Muscle Tissue Neoplasms
Smooth Muscle
Actins
Hemorrhage
Desmin
Myofibroblasts
Groin
Glial Fibrillary Acidic Protein
Cyclin D1
Lymphoid Tissue
Smooth Muscle Myocytes
Publications
Electron Microscopy
Coloring Agents
Erythrocytes
Recurrence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Nguyen, T., & Eltorky, M. A. (2007). Intranodal palisaded myofibroblastoma. Archives of Pathology and Laboratory Medicine, 131(2), 306-310.

Intranodal palisaded myofibroblastoma. / Nguyen, Thong; Eltorky, Mahmoud A.

In: Archives of Pathology and Laboratory Medicine, Vol. 131, No. 2, 02.2007, p. 306-310.

Research output: Contribution to journalArticle

Nguyen, T & Eltorky, MA 2007, 'Intranodal palisaded myofibroblastoma', Archives of Pathology and Laboratory Medicine, vol. 131, no. 2, pp. 306-310.
Nguyen, Thong ; Eltorky, Mahmoud A. / Intranodal palisaded myofibroblastoma. In: Archives of Pathology and Laboratory Medicine. 2007 ; Vol. 131, No. 2. pp. 306-310.
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