Vnutriselezenochnaia ksenotransplantatsiia kul'tur ostrovkovykh kletok podzheludochnoǐ zhelezy plodov cheloveka krysam s éksperimental'nym sakharnym diabetom.

Translated title of the contribution: Intrasplenic xenotransplantation of human fetal pancreatic islet cell cultures in rats with experimental diabetes mellitus

V. N. Bliumkin, N. N. Skaletskiǐ, Vsevolod Popov, B. I. Shal'nev, M. A. Danilov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Islet cell cultures obtained from the pancreas of human embryos were transplanted to the spleen pulp of rats with alloxan diabetes mellitus. During 1-2 weeks after transplantation, 6 of the 8 recipients manifested a decrease in glycemia to normal or almost normal. The antidiabetic effect of xenotransplantation of islet cell cultures was well preserved throughout the entire observation period (up to 4 months). Two recipient rats with stable normoglycemia were subjected to splenectomy. One week after operation the animals manifested the recurrent grave diabetic status. Histological study of the removed spleen has shown the red pulp to contain the accumulations of implanted islet cells.

Original languageUndefined
Pages (from-to)89-91
Number of pages3
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume95
Issue number5
StatePublished - May 1983
Externally publishedYes

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Heterologous Transplantation
Experimental Diabetes Mellitus
Medical problems
Islets of Langerhans
Cell culture
Pulp
Rats
Cell Culture Techniques
Alloxan
Spleen
Hypoglycemic Agents
Animals
Splenectomy
Pancreas
Diabetes Mellitus
Embryonic Structures
Transplantation
Observation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vnutriselezenochnaia ksenotransplantatsiia kul'tur ostrovkovykh kletok podzheludochnoǐ zhelezy plodov cheloveka krysam s éksperimental'nym sakharnym diabetom. / Bliumkin, V. N.; Skaletskiǐ, N. N.; Popov, Vsevolod; Shal'nev, B. I.; Danilov, M. A.

In: Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 95, No. 5, 05.1983, p. 89-91.

Research output: Contribution to journalArticle

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abstract = "Islet cell cultures obtained from the pancreas of human embryos were transplanted to the spleen pulp of rats with alloxan diabetes mellitus. During 1-2 weeks after transplantation, 6 of the 8 recipients manifested a decrease in glycemia to normal or almost normal. The antidiabetic effect of xenotransplantation of islet cell cultures was well preserved throughout the entire observation period (up to 4 months). Two recipient rats with stable normoglycemia were subjected to splenectomy. One week after operation the animals manifested the recurrent grave diabetic status. Histological study of the removed spleen has shown the red pulp to contain the accumulations of implanted islet cells.",
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