Intravenous β-endorphin administration fails to alter hypothalamic blood flow in rats expressing normal or reduced nihic oxide synthase activity

Zoltán Benyó, Csaba Szabó, Mária H. Velkei, Béla Bohus, Michael Wahl, Péter Sándor

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations

    Abstract

    -Endorphin (β-END) significantly contributes to the maintenance of hypothalamic blood flow (HBF) autoregulation during hemorrhagic hypotension in rats. Recently, several natural and synthetic opioid peptides were reported to induce nitric oxide (NO)-mediated dilation in the cerebrovascular bed. In the present study, the effect of β-END was studied on HBF and hypothalamic vascular resistance (HVR) in vehicle-treated control rats and in rats after the pharmacological inhibition of the NO synthesis by chronic oral application of N(G)-nitro-L-arginine methyl ester. Intravenous β-END administration faired to alter HBF or HVR either in control or in NO-blocked animals, and its transient hypotensive effect was not inhibited by NO blockade, indicating that β-END may not have NO-mediated vasodilator effect in the hypothalamic or in the systemic circulation.

    Original languageEnglish (US)
    Pages (from-to)733-736
    Number of pages4
    JournalPeptides
    Volume17
    Issue number4
    DOIs
    StatePublished - Jan 1 1996

    Keywords

    • -Endorphin
    • Cerebral blood flow autoregulation
    • Hypertension
    • Hypothalamus
    • N(G)-Nitro-L-arginine methyl ester (L-NAME)
    • Nitric oxide synthase blockade
    • Rat

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Endocrinology
    • Cellular and Molecular Neuroscience

    Fingerprint Dive into the research topics of 'Intravenous β-endorphin administration fails to alter hypothalamic blood flow in rats expressing normal or reduced nihic oxide synthase activity'. Together they form a unique fingerprint.

    Cite this