Intravenous β-endorphin administration fails to alter hypothalamic blood flow in rats expressing normal or reduced nihic oxide synthase activity

Zoltán Benyó, Csaba Szabo, Mária H. Velkei, Béla Bohus, Michael Wahl, Péter Sándor

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

-Endorphin (β-END) significantly contributes to the maintenance of hypothalamic blood flow (HBF) autoregulation during hemorrhagic hypotension in rats. Recently, several natural and synthetic opioid peptides were reported to induce nitric oxide (NO)-mediated dilation in the cerebrovascular bed. In the present study, the effect of β-END was studied on HBF and hypothalamic vascular resistance (HVR) in vehicle-treated control rats and in rats after the pharmacological inhibition of the NO synthesis by chronic oral application of N(G)-nitro-L-arginine methyl ester. Intravenous β-END administration faired to alter HBF or HVR either in control or in NO-blocked animals, and its transient hypotensive effect was not inhibited by NO blockade, indicating that β-END may not have NO-mediated vasodilator effect in the hypothalamic or in the systemic circulation.

Original languageEnglish (US)
Pages (from-to)733-736
Number of pages4
JournalPeptides
Volume17
Issue number4
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Endorphins
Intravenous Administration
Oxides
Rats
Nitric Oxide
Blood
Vascular Resistance
Rat control
Opioid Peptides
NG-Nitroarginine Methyl Ester
Vasodilator Agents
Hypotension
Dilatation
Animals
Homeostasis
Maintenance
Pharmacology

Keywords

  • -Endorphin
  • Cerebral blood flow autoregulation
  • Hypertension
  • Hypothalamus
  • N(G)-Nitro-L-arginine methyl ester (L-NAME)
  • Nitric oxide synthase blockade
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Intravenous β-endorphin administration fails to alter hypothalamic blood flow in rats expressing normal or reduced nihic oxide synthase activity. / Benyó, Zoltán; Szabo, Csaba; Velkei, Mária H.; Bohus, Béla; Wahl, Michael; Sándor, Péter.

In: Peptides, Vol. 17, No. 4, 1996, p. 733-736.

Research output: Contribution to journalArticle

Benyó, Zoltán ; Szabo, Csaba ; Velkei, Mária H. ; Bohus, Béla ; Wahl, Michael ; Sándor, Péter. / Intravenous β-endorphin administration fails to alter hypothalamic blood flow in rats expressing normal or reduced nihic oxide synthase activity. In: Peptides. 1996 ; Vol. 17, No. 4. pp. 733-736.
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