Intravenous amino acids stimulate human gallbaldder emptying and hormone release

W. H. Nealon, J. R. Upp, R. W. Alexander, Guillermo Gomez, Courtney Townsend, J. C. Thompson

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Gallbladder stasis during prolonged total parenteral nutrition (TPN) has been documented. We have examined the effect of intravenous amino acid infusion on human gallbladder contraction and release of cholecystokinin (CCK). Five healthy adult volunteers were given amino acid infusions at different rates (65, 125, 240, and 600 mg · kg-1 · h-1). The volume of the gallbladder was calculated by means of ultrasonographic measurements. Plasma samples were analyzed for CCK immunoreactivity. Gallbladder and hormone responses after intravenous amino acids were compared with responses after a fat meal, after a protein meal, and after ingestion of an oral amino acid mixture. We found that intravenous amino acids stimulated human gallbladder contraction in a dose-related manner. The mechanism of stimulation may be through the release of CCK although significant correlation was not demonstrated. The magnitude of response is similar to that seen after meal stimulation. To compare the delivery of amino acids during a standard meal and during each dose of intravenous amino acids, peripheral plasma levels of dietary amino acids were measured after a standard commercially prepared enteral supplement meal and after each dose of intravenous amino acids. Our lower doses of amino acid infused resulted in levels of circulating amino acid comparable to those after a meal. The induction of gallbladder contraction and release of CCK in human recipients of parenteral nutrition may be of value in some circumstances.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume259
Issue number2 22-2
StatePublished - 1990

Fingerprint

Hormones
Amino Acids
Gallbladder
Meals
Cholecystokinin
Total Parenteral Nutrition
Parenteral Nutrition
Small Intestine
Healthy Volunteers
Eating
Fats
Proteins

Keywords

  • Cholecystokinin
  • Cholestasis
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Intravenous amino acids stimulate human gallbaldder emptying and hormone release. / Nealon, W. H.; Upp, J. R.; Alexander, R. W.; Gomez, Guillermo; Townsend, Courtney; Thompson, J. C.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 259, No. 2 22-2, 1990.

Research output: Contribution to journalArticle

Nealon, W. H. ; Upp, J. R. ; Alexander, R. W. ; Gomez, Guillermo ; Townsend, Courtney ; Thompson, J. C. / Intravenous amino acids stimulate human gallbaldder emptying and hormone release. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1990 ; Vol. 259, No. 2 22-2.
@article{e7214542deac4f81b82ae894e4077d97,
title = "Intravenous amino acids stimulate human gallbaldder emptying and hormone release",
abstract = "Gallbladder stasis during prolonged total parenteral nutrition (TPN) has been documented. We have examined the effect of intravenous amino acid infusion on human gallbladder contraction and release of cholecystokinin (CCK). Five healthy adult volunteers were given amino acid infusions at different rates (65, 125, 240, and 600 mg · kg-1 · h-1). The volume of the gallbladder was calculated by means of ultrasonographic measurements. Plasma samples were analyzed for CCK immunoreactivity. Gallbladder and hormone responses after intravenous amino acids were compared with responses after a fat meal, after a protein meal, and after ingestion of an oral amino acid mixture. We found that intravenous amino acids stimulated human gallbladder contraction in a dose-related manner. The mechanism of stimulation may be through the release of CCK although significant correlation was not demonstrated. The magnitude of response is similar to that seen after meal stimulation. To compare the delivery of amino acids during a standard meal and during each dose of intravenous amino acids, peripheral plasma levels of dietary amino acids were measured after a standard commercially prepared enteral supplement meal and after each dose of intravenous amino acids. Our lower doses of amino acid infused resulted in levels of circulating amino acid comparable to those after a meal. The induction of gallbladder contraction and release of CCK in human recipients of parenteral nutrition may be of value in some circumstances.",
keywords = "Cholecystokinin, Cholestasis, Total parenteral nutrition",
author = "Nealon, {W. H.} and Upp, {J. R.} and Alexander, {R. W.} and Guillermo Gomez and Courtney Townsend and Thompson, {J. C.}",
year = "1990",
language = "English (US)",
volume = "259",
journal = "American Journal of Physiology - Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "2 22-2",

}

TY - JOUR

T1 - Intravenous amino acids stimulate human gallbaldder emptying and hormone release

AU - Nealon, W. H.

AU - Upp, J. R.

AU - Alexander, R. W.

AU - Gomez, Guillermo

AU - Townsend, Courtney

AU - Thompson, J. C.

PY - 1990

Y1 - 1990

N2 - Gallbladder stasis during prolonged total parenteral nutrition (TPN) has been documented. We have examined the effect of intravenous amino acid infusion on human gallbladder contraction and release of cholecystokinin (CCK). Five healthy adult volunteers were given amino acid infusions at different rates (65, 125, 240, and 600 mg · kg-1 · h-1). The volume of the gallbladder was calculated by means of ultrasonographic measurements. Plasma samples were analyzed for CCK immunoreactivity. Gallbladder and hormone responses after intravenous amino acids were compared with responses after a fat meal, after a protein meal, and after ingestion of an oral amino acid mixture. We found that intravenous amino acids stimulated human gallbladder contraction in a dose-related manner. The mechanism of stimulation may be through the release of CCK although significant correlation was not demonstrated. The magnitude of response is similar to that seen after meal stimulation. To compare the delivery of amino acids during a standard meal and during each dose of intravenous amino acids, peripheral plasma levels of dietary amino acids were measured after a standard commercially prepared enteral supplement meal and after each dose of intravenous amino acids. Our lower doses of amino acid infused resulted in levels of circulating amino acid comparable to those after a meal. The induction of gallbladder contraction and release of CCK in human recipients of parenteral nutrition may be of value in some circumstances.

AB - Gallbladder stasis during prolonged total parenteral nutrition (TPN) has been documented. We have examined the effect of intravenous amino acid infusion on human gallbladder contraction and release of cholecystokinin (CCK). Five healthy adult volunteers were given amino acid infusions at different rates (65, 125, 240, and 600 mg · kg-1 · h-1). The volume of the gallbladder was calculated by means of ultrasonographic measurements. Plasma samples were analyzed for CCK immunoreactivity. Gallbladder and hormone responses after intravenous amino acids were compared with responses after a fat meal, after a protein meal, and after ingestion of an oral amino acid mixture. We found that intravenous amino acids stimulated human gallbladder contraction in a dose-related manner. The mechanism of stimulation may be through the release of CCK although significant correlation was not demonstrated. The magnitude of response is similar to that seen after meal stimulation. To compare the delivery of amino acids during a standard meal and during each dose of intravenous amino acids, peripheral plasma levels of dietary amino acids were measured after a standard commercially prepared enteral supplement meal and after each dose of intravenous amino acids. Our lower doses of amino acid infused resulted in levels of circulating amino acid comparable to those after a meal. The induction of gallbladder contraction and release of CCK in human recipients of parenteral nutrition may be of value in some circumstances.

KW - Cholecystokinin

KW - Cholestasis

KW - Total parenteral nutrition

UR - http://www.scopus.com/inward/record.url?scp=0025003549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025003549&partnerID=8YFLogxK

M3 - Article

VL - 259

JO - American Journal of Physiology - Endocrinology and Metabolism

JF - American Journal of Physiology - Endocrinology and Metabolism

SN - 0193-1849

IS - 2 22-2

ER -