Intravenous antidepressants

A review

Nidal J. Moukaddam, Robert M A Hirschfeld

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Antidepressant medications have an onset of action of several weeks and have moderate efficacy. Their mode of administration is oral (p.o.). Some clinicians wondered whether intravenous (i.v.) administration would speed onset of action and increase efficacy. In this article we review controlled studies on i.v. administration of antidepressants. These include clomipramine, citalopram, and other antidepressants. Overall these studies do not support increased efficacy of i.v. over p.o. administration but there are suggestions of a faster onset of action. In one study i.v. citalopram showed superior response rates over p.o. citalopram (79% vs. 63%) in severely depressed patients at 8 weeks.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalDepression and Anxiety
Volume19
Issue number1
DOIs
StatePublished - 2004

Fingerprint

Citalopram
Antidepressive Agents
Intravenous Administration
Clomipramine
Oral Administration

Keywords

  • Antidepressive agents
  • Citalopram
  • Clomipramine
  • Depression
  • Depressive disorder
  • Selective serotonin uptake inhibitors
  • Tricyclics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Moukaddam, N. J., & Hirschfeld, R. M. A. (2004). Intravenous antidepressants: A review. Depression and Anxiety, 19(1), 1-9. https://doi.org/10.1002/da.10135

Intravenous antidepressants : A review. / Moukaddam, Nidal J.; Hirschfeld, Robert M A.

In: Depression and Anxiety, Vol. 19, No. 1, 2004, p. 1-9.

Research output: Contribution to journalArticle

Moukaddam, NJ & Hirschfeld, RMA 2004, 'Intravenous antidepressants: A review', Depression and Anxiety, vol. 19, no. 1, pp. 1-9. https://doi.org/10.1002/da.10135
Moukaddam, Nidal J. ; Hirschfeld, Robert M A. / Intravenous antidepressants : A review. In: Depression and Anxiety. 2004 ; Vol. 19, No. 1. pp. 1-9.
@article{3dadae2521e341f7a67890a97d81ba85,
title = "Intravenous antidepressants: A review",
abstract = "Antidepressant medications have an onset of action of several weeks and have moderate efficacy. Their mode of administration is oral (p.o.). Some clinicians wondered whether intravenous (i.v.) administration would speed onset of action and increase efficacy. In this article we review controlled studies on i.v. administration of antidepressants. These include clomipramine, citalopram, and other antidepressants. Overall these studies do not support increased efficacy of i.v. over p.o. administration but there are suggestions of a faster onset of action. In one study i.v. citalopram showed superior response rates over p.o. citalopram (79{\%} vs. 63{\%}) in severely depressed patients at 8 weeks.",
keywords = "Antidepressive agents, Citalopram, Clomipramine, Depression, Depressive disorder, Selective serotonin uptake inhibitors, Tricyclics",
author = "Moukaddam, {Nidal J.} and Hirschfeld, {Robert M A}",
year = "2004",
doi = "10.1002/da.10135",
language = "English (US)",
volume = "19",
pages = "1--9",
journal = "Depression and Anxiety",
issn = "1091-4269",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Intravenous antidepressants

T2 - A review

AU - Moukaddam, Nidal J.

AU - Hirschfeld, Robert M A

PY - 2004

Y1 - 2004

N2 - Antidepressant medications have an onset of action of several weeks and have moderate efficacy. Their mode of administration is oral (p.o.). Some clinicians wondered whether intravenous (i.v.) administration would speed onset of action and increase efficacy. In this article we review controlled studies on i.v. administration of antidepressants. These include clomipramine, citalopram, and other antidepressants. Overall these studies do not support increased efficacy of i.v. over p.o. administration but there are suggestions of a faster onset of action. In one study i.v. citalopram showed superior response rates over p.o. citalopram (79% vs. 63%) in severely depressed patients at 8 weeks.

AB - Antidepressant medications have an onset of action of several weeks and have moderate efficacy. Their mode of administration is oral (p.o.). Some clinicians wondered whether intravenous (i.v.) administration would speed onset of action and increase efficacy. In this article we review controlled studies on i.v. administration of antidepressants. These include clomipramine, citalopram, and other antidepressants. Overall these studies do not support increased efficacy of i.v. over p.o. administration but there are suggestions of a faster onset of action. In one study i.v. citalopram showed superior response rates over p.o. citalopram (79% vs. 63%) in severely depressed patients at 8 weeks.

KW - Antidepressive agents

KW - Citalopram

KW - Clomipramine

KW - Depression

KW - Depressive disorder

KW - Selective serotonin uptake inhibitors

KW - Tricyclics

UR - http://www.scopus.com/inward/record.url?scp=1542290335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542290335&partnerID=8YFLogxK

U2 - 10.1002/da.10135

DO - 10.1002/da.10135

M3 - Article

VL - 19

SP - 1

EP - 9

JO - Depression and Anxiety

JF - Depression and Anxiety

SN - 1091-4269

IS - 1

ER -