Intravenous immune globulin therapy. Treatment of a patient with severe immunodeficiency, chronic malabsorption, and fulminant septicemia

Emilio Gonzalez, B. G. Guernsey, N. B. Ingrim, Y. Ichikawa, J. C. Daniels

Research output: Contribution to journalArticle

Abstract

Biweekly 200 mg/kg infusions of immune globulin (Gamimune) were given to a 46-year-old woman with severe common variable immunodeficiency, bronchiectasis, and chronic diarrhea with malabsorption. Failure to achieve therapeutically effective serum IgG concentrations in the face of fulminant sepsis was accompanied by a shortened serum IgG half-life of 10.6 days. Currently recommended doses of 200 mg/kg may prove inadequate in very ill patients with sepsis and malabsorption.

Original languageEnglish (US)
Pages (from-to)945-946
Number of pages2
JournalArchives of Internal Medicine
Volume145
Issue number5
DOIs
StatePublished - 1985

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ASJC Scopus subject areas

  • Internal Medicine

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