Intravenous Iron Compared with Oral Iron Supplementation for the Treatment of Postpartum Anemia: A Randomized Controlled Trial

Antonio F. Saad, Rachel Stepanek, Makenzie Kothmann, Maria Wilson-Jimenez, Leah McCoy, Brenda Aguillon, Ashley Salazar, George R. Saade

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Postpartum anemia is a significant maternal comorbidity that affects 50%of patients in the United States. It has been associated with maternal impaired cognition, depression, and fatigue, ultimately affecting mother-child bonding and neonatal care. Oral iron supplementation is currently the first-line treatment for women with iron-deficiency anemia postpartum. The effectiveness of oral iron is diminished by variability in absorption, discomforting side effects, and poor compliance, limitations that can be overcome with intravenous (IV) iron. However, IV iron is costly and needs to be administered under supervision in a hospital or outpatient clinical setting. We performed a pragmatic, double-blinded, feasibility randomized controlled trial of daily oral compared with IV iron administered after delivery but before hospital discharge. We found that patients randomized to IV iron had higher hemoglobin levels after 6 weeks postpartum than those randomized to oral iron. Our trial shows that it is feasible to administer IV iron during the delivery admission and that larger multicenter clinical trials are warranted.CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov, NCT05047211.

Original languageEnglish (US)
Pages (from-to)1052-1055
Number of pages4
JournalObstetrics and gynecology
Volume141
Issue number6
DOIs
StatePublished - Jun 1 2023

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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