Intraventricular infusion of nerve growth factor as the cause of sympathetic fiber sprouting in sensory ganglia

Haring J W Nauta, Joseph C. Wehman, Vassilis E. Koliatsos, Marylee A. Terrell, Kyungsoon Chung

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Object. The results of previous clinical trials have indicated that intraventricular infusion of nerve growth factor (NGF) in patients with Alzheimer's disease is frustrated by the appearance of weight loss and diffuse back pain. The present study tested whether NGF induces sympathetic sprouting in sensory ganglia. Such sprouting has been implicated in previous studies as a possible mechanism of sympathetically maintained pain in neuropathic animals. Methods. Nineteen Long-Evans rats underwent intraventricular infusion of either artificial cerebrospinal fluid (ACSF; seven animals) or NGF (12 animals). After 14 days of infusion, the sensory ganglia of the trigeminal nerve and the C-2, C-8, T-1, L-4, and L-5 dorsal roots were examined for sympathetic sprouting by using tyrosine hydroxylase immunohistochemical analysis. Conclusions. In the animals receiving NGF, 52 of 144 ganglia showed sympathetic fiber sprouting. In the control animals receiving ACSF, only two of 72 ganglia showed minor sympathetic fiber sprouting. A preferential sprouting of sympathetic fibers was demonstrated at lower lumbar ganglia compared with the cervical and thoracic ganglia. The data presented here demonstrate that in the rat intraventricular NGF infusion caused sympathetic sprouting in dorsal root ganglia (p <0.01). These findings may have importance both for the treatment of Alzheimer's disease and the understanding of neuropathic pain.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalJournal of Neurosurgery
Volume91
Issue number3
StatePublished - Sep 1999

Fingerprint

Sensory Ganglia
Intraventricular Infusions
Adrenergic Fibers
Nerve Growth Factor
Ganglia
Neuralgia
Alzheimer Disease
Long Evans Rats
Trigeminal Nerve
Spinal Nerve Roots
Tyrosine 3-Monooxygenase
Spinal Ganglia
Back Pain
Cerebrospinal Fluid
Weight Loss
Thorax
Clinical Trials

Keywords

  • Alzheimer's disease
  • Nerve growth factor
  • Pain
  • Therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Nauta, H. J. W., Wehman, J. C., Koliatsos, V. E., Terrell, M. A., & Chung, K. (1999). Intraventricular infusion of nerve growth factor as the cause of sympathetic fiber sprouting in sensory ganglia. Journal of Neurosurgery, 91(3), 447-453.

Intraventricular infusion of nerve growth factor as the cause of sympathetic fiber sprouting in sensory ganglia. / Nauta, Haring J W; Wehman, Joseph C.; Koliatsos, Vassilis E.; Terrell, Marylee A.; Chung, Kyungsoon.

In: Journal of Neurosurgery, Vol. 91, No. 3, 09.1999, p. 447-453.

Research output: Contribution to journalArticle

Nauta, HJW, Wehman, JC, Koliatsos, VE, Terrell, MA & Chung, K 1999, 'Intraventricular infusion of nerve growth factor as the cause of sympathetic fiber sprouting in sensory ganglia', Journal of Neurosurgery, vol. 91, no. 3, pp. 447-453.
Nauta, Haring J W ; Wehman, Joseph C. ; Koliatsos, Vassilis E. ; Terrell, Marylee A. ; Chung, Kyungsoon. / Intraventricular infusion of nerve growth factor as the cause of sympathetic fiber sprouting in sensory ganglia. In: Journal of Neurosurgery. 1999 ; Vol. 91, No. 3. pp. 447-453.
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