Introduction to asthma and phenotyping

Regina A. Pillai, William J. Calhoun

Research output: Chapter in Book/Report/Conference proceedingChapter


Asthma is an inflammatory disorder characterized by airway obstruction, airway hyperresponsiveness, and airway inflammation, all of which are variable among patients and variable in time within any specific patient. Understanding the mechanism that underlies this observed variability, and using that understanding to advance the science of asthma and the care of asthmatic patients, is an essential purpose of developing phenotypes. Clinical phenotypes have been used for decades, but overlap each other, and do not map cleanly to either pathophysiologic mechanism or with therapeutic response. Molecular phenotyping, although as yet only partially developed, offers the promise of dissecting the mechanistic underpinnings of the variability of asthma and of providing predictive therapeutics for the benefit of patients with this common and troubling disease.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages11
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)00652598


  • Asthma
  • Clinical phenotypes
  • Clusters
  • Heterogeneity
  • Induced phenotype
  • Molecular phenotype
  • Physiology
  • Treatment

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


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