Introduction to asthma and phenotyping

Regina A. Pillai, William Calhoun

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Asthma is an inflammatory disorder characterized by airway obstruction, airway hyperresponsiveness, and airway inflammation, all of which are variable among patients and variable in time within any specific patient. Understanding the mechanism that underlies this observed variability, and using that understanding to advance the science of asthma and the care of asthmatic patients, is an essential purpose of developing phenotypes. Clinical phenotypes have been used for decades, but overlap each other, and do not map cleanly to either pathophysiologic mechanism or with therapeutic response. Molecular phenotyping, although as yet only partially developed, offers the promise of dissecting the mechanistic underpinnings of the variability of asthma and of providing predictive therapeutics for the benefit of patients with this common and troubling disease.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages5-15
Number of pages11
Volume795
ISBN (Print)9781461486022
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume795
ISSN (Print)00652598

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Keywords

  • Asthma
  • Clinical phenotypes
  • Clusters
  • Heterogeneity
  • Induced phenotype
  • Molecular phenotype
  • Physiology
  • Treatment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Pillai, R. A., & Calhoun, W. (2014). Introduction to asthma and phenotyping. In Advances in Experimental Medicine and Biology (Vol. 795, pp. 5-15). (Advances in Experimental Medicine and Biology; Vol. 795). Springer New York LLC. https://doi.org/10.1007/978-1-4614-8603-9_1