Investigation of new flow modifying endovascular image-guided interventional (EIGI) techniques in patient-specific aneurysm phantoms (PSAPs) using optical imaging

J. R. Sherman, H. S. Rangwala, C. N. Ionita, A. C. Dohatcu, J. W. Lee, D. R. Bednarek, K. R. Hoffmann, S. Rudin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations

Abstract

Effective minimally invasive treatment of cerebral bifurcation aneurysms is challenging due to the complex and remote vessel morphology. An evaluation of endovascular treatment in a phantom involving image-guided deployment of new asymmetric stents consisting of polyurethane patches placed to modify blood flow into the aneurysm is reported. The 3D lumen-geometry of a patient-specific basilar-artery bifurcation aneurysm was derived from a segmented computed-tomography dataset. This was used in a stereolithographic rapid-prototyping process to generate a mold which was then used to create any number of exact wax models. These models in turn were used in a lost-wax technique to create transparent elastomer patient-specific aneurysm phantoms (PSAP) for evaluating the effectiveness of asymmetric-stent deployment for flow modification. Flow was studied by recording real-time digitized video images of optical dye in the PSAP and its feeding vessel. For two asymmetric stent placements: through the basilar into the right-posterior communicating artery (RPCA) and through the basilar into the left-posterior communicating artery (LPCA), the greatest deviation of flow streamlines away from the aneurysm occurred for the RPCA stent deployment. Flow was also substantially affected by variations of inflow angle into the basilar artery, resulting in alternations in washout times as derived from time-density curves. Evaluation of flow in the PSAPs with real-time optical imaging can be used to determine new EIGI effectiveness and to validate computational-fluid-dynamic calculations for ElGl-treatment planning.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Visualization, Image-Guided Procedures, and Modeling
Volume6918
DOIs
StatePublished - 2008
Externally publishedYes
EventMedical Imaging 2008 - Visualization, Image-Guided Procedures, and Modeling - San Diego, CA, United States
Duration: Feb 17 2008Feb 19 2008

Other

OtherMedical Imaging 2008 - Visualization, Image-Guided Procedures, and Modeling
CountryUnited States
CitySan Diego, CA
Period2/17/082/19/08

Keywords

  • Image-guided therapy
  • Modeling
  • Neurosurgical procedures
  • Procedure simulation
  • Segmentation and rendering
  • Treatment planning

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Sherman, J. R., Rangwala, H. S., Ionita, C. N., Dohatcu, A. C., Lee, J. W., Bednarek, D. R., Hoffmann, K. R., & Rudin, S. (2008). Investigation of new flow modifying endovascular image-guided interventional (EIGI) techniques in patient-specific aneurysm phantoms (PSAPs) using optical imaging. In Medical Imaging 2008 - Visualization, Image-Guided Procedures, and Modeling (Vol. 6918). [69181V] https://doi.org/10.1117/12.772583