Abstract
A simple and efficient method for regioselective synthesis of 3-arylquinolines is described from α-aminoacetophenones and trans-β-nitrostyrenes using 20 mol% iodine monobromide as a catalyst in acetonitrile solvent at 80 °C. The present method involves tandem reaction of α-aminoacetophenones and trans-β-nitrostyrenes, formation of two new C-C bonds and cleavage of one C-C bond in a single step. The salient features of the protocol are metal- and oxidant-free reaction conditions, broad substrate scope, and good yields.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 347-353 |
| Number of pages | 7 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2019 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry