Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions

Francisco A. Fernandez-Lima, Christopher Becker, Kent J. Gillig, William Russell, Shane E. Tichy, David H. Russell

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An ion mobility-mass spectrometer (IM-MS) interface is described that can be employed to perform collisional activation and/or collision-induced dissociation (CID) with good transmission of mobility separated ions to the MS analyzer. The IM-MS interface consists of a stacked-ring ion guide design, where the field strength and pressure ratio can be operated such that structural rearrangement reactions and/or CID are achieved as a function of the effective ion temperature. The ion dynamics and collisional activation processes in the IM-MS interface are described as a function of the ion-neutral collisions, ion kinetic energies, and effective ion temperature. The applicability of the IM-CID-MS methodology to studies of peptide ion fragmentation is illustrated using a series of model peptides.

Original languageEnglish (US)
Pages (from-to)618-624
Number of pages7
JournalAnalytical Chemistry
Volume81
Issue number2
DOIs
StatePublished - Jan 15 2009
Externally publishedYes

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Ion mobility spectrometers
Mass spectrometers
Chemical activation
Ions
Peptides
Kinetic energy

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Fernandez-Lima, F. A., Becker, C., Gillig, K. J., Russell, W., Tichy, S. E., & Russell, D. H. (2009). Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions. Analytical Chemistry, 81(2), 618-624. https://doi.org/10.1021/ac801919n

Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions. / Fernandez-Lima, Francisco A.; Becker, Christopher; Gillig, Kent J.; Russell, William; Tichy, Shane E.; Russell, David H.

In: Analytical Chemistry, Vol. 81, No. 2, 15.01.2009, p. 618-624.

Research output: Contribution to journalArticle

Fernandez-Lima, FA, Becker, C, Gillig, KJ, Russell, W, Tichy, SE & Russell, DH 2009, 'Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions', Analytical Chemistry, vol. 81, no. 2, pp. 618-624. https://doi.org/10.1021/ac801919n
Fernandez-Lima, Francisco A. ; Becker, Christopher ; Gillig, Kent J. ; Russell, William ; Tichy, Shane E. ; Russell, David H. / Ion mobility-mass spectrometer interface for collisional activation of mobility separated ions. In: Analytical Chemistry. 2009 ; Vol. 81, No. 2. pp. 618-624.
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