Iproniazid-induced biochemical changes in mice

R. P. Maickel, D. R. Bowman, N. Fedynskyj, W. R. Snodgrass, M. P. Ryan

Research output: Contribution to journalArticle

1 Scopus citations


Single doses of iproniazid to Swiss-Webster mice caused a prolonged hypoglycemic reaction and transient biphasic changes in liver triglycerides. In contrast, the same dose of iproniazid in mice on a pyridoxine deficient diet elevated plasma glucose and FFA and liver FFA and TGL. Administration of the same dose of ipioniazid for 30 days elevated liver TGL in Swiss-Webster, C57/B1, DBA, and AKR mice; this effect was reversed in all but the aKR mice when the animals were maintained on a pyridoxine-deficient diet.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number1
StatePublished - 1979
Externally publishedYes


ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Maickel, R. P., Bowman, D. R., Fedynskyj, N., Snodgrass, W. R., & Ryan, M. P. (1979). Iproniazid-induced biochemical changes in mice. Research Communications in Chemical Pathology and Pharmacology, 25(1), 131-141.