Abstract
Single doses of iproniazid to Swiss-Webster mice caused a prolonged hypoglycemic reaction and transient biphasic changes in liver triglycerides. In contrast, the same dose of iproniazid in mice on a pyridoxine deficient diet elevated plasma glucose and FFA and liver FFA and TGL. Administration of the same dose of ipioniazid for 30 days elevated liver TGL in Swiss-Webster, C57/B1, DBA, and AKR mice; this effect was reversed in all but the aKR mice when the animals were maintained on a pyridoxine-deficient diet.
Original language | English (US) |
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Pages (from-to) | 131-141 |
Number of pages | 11 |
Journal | Research Communications in Chemical Pathology and Pharmacology |
Volume | 25 |
Issue number | 1 |
State | Published - 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology