Iproniazid-induced biochemical changes in mice

R. P. Maickel, D. R. Bowman, N. Fedynskyj, W. R. Snodgrass, M. P. Ryan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Single doses of iproniazid to Swiss-Webster mice caused a prolonged hypoglycemic reaction and transient biphasic changes in liver triglycerides. In contrast, the same dose of iproniazid in mice on a pyridoxine deficient diet elevated plasma glucose and FFA and liver FFA and TGL. Administration of the same dose of ipioniazid for 30 days elevated liver TGL in Swiss-Webster, C57/B1, DBA, and AKR mice; this effect was reversed in all but the aKR mice when the animals were maintained on a pyridoxine-deficient diet.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume25
Issue number1
StatePublished - 1979
Externally publishedYes

Fingerprint

Iproniazid
Liver
Pyridoxine
Nutrition
Inbred AKR Mouse
Diet
Inbred DBA Mouse
Hypoglycemic Agents
Animals
Triglycerides
Plasmas
Glucose

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Maickel, R. P., Bowman, D. R., Fedynskyj, N., Snodgrass, W. R., & Ryan, M. P. (1979). Iproniazid-induced biochemical changes in mice. Research Communications in Chemical Pathology and Pharmacology, 25(1), 131-141.

Iproniazid-induced biochemical changes in mice. / Maickel, R. P.; Bowman, D. R.; Fedynskyj, N.; Snodgrass, W. R.; Ryan, M. P.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 25, No. 1, 1979, p. 131-141.

Research output: Contribution to journalArticle

Maickel, RP, Bowman, DR, Fedynskyj, N, Snodgrass, WR & Ryan, MP 1979, 'Iproniazid-induced biochemical changes in mice', Research Communications in Chemical Pathology and Pharmacology, vol. 25, no. 1, pp. 131-141.
Maickel RP, Bowman DR, Fedynskyj N, Snodgrass WR, Ryan MP. Iproniazid-induced biochemical changes in mice. Research Communications in Chemical Pathology and Pharmacology. 1979;25(1):131-141.
Maickel, R. P. ; Bowman, D. R. ; Fedynskyj, N. ; Snodgrass, W. R. ; Ryan, M. P. / Iproniazid-induced biochemical changes in mice. In: Research Communications in Chemical Pathology and Pharmacology. 1979 ; Vol. 25, No. 1. pp. 131-141.
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