Iquitos virus

A novel reassortant orthobunyavirus associated with human illness in peru

Patricia Aguilar, Alan Barrett, Mohammad F. Saeed, Douglas M. Watts, Kevin Russell, Carolina Guevara, Julia S. Ampuero, Luis Suarez, Manuel Cespedes, Joel M. Montgomery, Eric S. Halsey, Tadeusz J. Kochel

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Oropouche (ORO) virus, a member of the Simbu serogroup, is one of the few human pathogens in the Orthobunyavirus genus in the family Bunyaviridae. Genetic analyses of ORO-like strains from Iquitos, Peru, identified a novel reassortant containing the S and L segments of ORO virus and the M segment of a novel Simbu serogroup virus. This new pathogen, which we named Iquitos (IQT) virus, was first isolated during 1999 from a febrile patient in Iquitos, an Amazonian city in Peru. Subsequently, the virus was identified as the cause of outbreaks of "Oropouche fever" during 2005 and 2006 in Iquitos. In addition to the identification of 17 isolates of IQT virus between 1999 and 2006, surveys for neutralizing antibody among Iquitos residents revealed prevalence rates of 14.9% for ORO virus and 15.4% for IQT virus. Limited studies indicate that prior infection with ORO virus does not seem to protect against disease caused with the IQT virus infection. Identification of a new Orthobunyavirus human pathogen in the Amazon region of Peru highlights the need for strengthening surveillance activities and laboratory capabilities, and investigating the emergence of new pathogens in tropical regions of South America.

Original languageEnglish (US)
Article numbere1315
JournalPLoS Neglected Tropical Diseases
Volume5
Issue number9
DOIs
StatePublished - Sep 2011

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Orthobunyavirus
Peru
Viruses
Simbu virus
Fever
Bunyaviridae
South America
Virus Diseases
Neutralizing Antibodies
Disease Outbreaks

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Iquitos virus : A novel reassortant orthobunyavirus associated with human illness in peru. / Aguilar, Patricia; Barrett, Alan; Saeed, Mohammad F.; Watts, Douglas M.; Russell, Kevin; Guevara, Carolina; Ampuero, Julia S.; Suarez, Luis; Cespedes, Manuel; Montgomery, Joel M.; Halsey, Eric S.; Kochel, Tadeusz J.

In: PLoS Neglected Tropical Diseases, Vol. 5, No. 9, e1315, 09.2011.

Research output: Contribution to journalArticle

Aguilar, P, Barrett, A, Saeed, MF, Watts, DM, Russell, K, Guevara, C, Ampuero, JS, Suarez, L, Cespedes, M, Montgomery, JM, Halsey, ES & Kochel, TJ 2011, 'Iquitos virus: A novel reassortant orthobunyavirus associated with human illness in peru', PLoS Neglected Tropical Diseases, vol. 5, no. 9, e1315. https://doi.org/10.1371/journal.pntd.0001315
Aguilar, Patricia ; Barrett, Alan ; Saeed, Mohammad F. ; Watts, Douglas M. ; Russell, Kevin ; Guevara, Carolina ; Ampuero, Julia S. ; Suarez, Luis ; Cespedes, Manuel ; Montgomery, Joel M. ; Halsey, Eric S. ; Kochel, Tadeusz J. / Iquitos virus : A novel reassortant orthobunyavirus associated with human illness in peru. In: PLoS Neglected Tropical Diseases. 2011 ; Vol. 5, No. 9.
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abstract = "Oropouche (ORO) virus, a member of the Simbu serogroup, is one of the few human pathogens in the Orthobunyavirus genus in the family Bunyaviridae. Genetic analyses of ORO-like strains from Iquitos, Peru, identified a novel reassortant containing the S and L segments of ORO virus and the M segment of a novel Simbu serogroup virus. This new pathogen, which we named Iquitos (IQT) virus, was first isolated during 1999 from a febrile patient in Iquitos, an Amazonian city in Peru. Subsequently, the virus was identified as the cause of outbreaks of {"}Oropouche fever{"} during 2005 and 2006 in Iquitos. In addition to the identification of 17 isolates of IQT virus between 1999 and 2006, surveys for neutralizing antibody among Iquitos residents revealed prevalence rates of 14.9{\%} for ORO virus and 15.4{\%} for IQT virus. Limited studies indicate that prior infection with ORO virus does not seem to protect against disease caused with the IQT virus infection. Identification of a new Orthobunyavirus human pathogen in the Amazon region of Peru highlights the need for strengthening surveillance activities and laboratory capabilities, and investigating the emergence of new pathogens in tropical regions of South America.",
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